Table 2.
A list of miRNAs with their respective clinical applications in CRCLM
| miRNAs | sample | Source of sample | Clinical application/biological function | References |
|---|---|---|---|---|
| miR-29a | Serum | CRCLM | Early detection | 26 |
| miR-126 | Serum | CRC/CRCLM | Early detection | 27 |
| miR-141 | Serum | CRC/CRCLM | Early detection | 27 |
| miR-21 | Serum | CRC/CRCLM | Early detection | 27 |
| miR-29 | Tissue mouse model) | CRC/CRCLM | Therapeutic target | 28 |
| miR-622 | Tissue/cell lines | CRC/CRCLM | Therapeutic target | 29 |
| miR-21 | Cell lines/CAM module | CRC/CRCLM | Therapeutic target | 30 |
| miR-655-3p | Tissue (mouse model) | CRC/CRCLM | Therapeutic target | 31 |
| miR-424-3p,503,1292 (combine together) | Tissue | CRC/CRCLM | Therapeutic target | 32 |
| let-7i | Tissue/serum | CRC/CRCLM | Prognostic | 33 |
| miR-10b | Tissue/serum | CRC/CRCLM | Prognostic | 34, 38 |
| miR-885-5p | Serum | CRC/CRCLM | Prognostic | 33 |
| miR-214 | Tissue | CRC/CRCLM | Prognostic | 35 |
| miR-625 | Tissue | CRC/CRCLM | Prognostic | 36 |
| miR-122 | Tissue | CRC/CRCLM | Prognostic | 37 |
| miR-196b-5p | Tissue | CRC/CRCLM | Prognostic | 39 |
| miR-203 | Serum | CRC/CRCLM | Prognostic | 40, 41 |
| Exo-miR-19a, 19b, 23a, 92a, 320a, 4437,19a | Serum | CRC/CRCLM | Predict liver metastasis | 45 |
| Exo-miR-19a | Serum | CRC/CRCLM | Prognostic | 45 |
| Exo-miR-7,181a-5p,192,194,375 | Serum/cell culture medium | CRC/CRCLM | Inflammation, fibrosis, angiogenesis | 48 |
| Exo-miR-210 | Tissue | CRC/CRCLM | carcinogenesis, migration | 50 |
| Exo-miR-193a | Tissue (mouse model) | CRC/CRCLM | Migration | 51 |