Table 3.
Effect of administration of FHE on hepatic function markers and renal function parameters.
| Control | Control Recovery | 250 mg/Kg | 500 mg/Kg | 1000 mg/Kg | High dose Recovery | |
|---|---|---|---|---|---|---|
| MALE | ||||||
| ALT (U/L) | 63.5 ± 26.9 | 71.6 ± 16.9 | 72 ± 14.8 | 64.1 ± 24 | 66.9 ± 16.6 | 40.6 ± 2.3 |
| AST (U/L) | 142 ± 25.2 | 160.4 ± 22.5 | 147.6 ± 16.1 | 138.4 ± 19.4 | 135.8 ± 24.6 | 156.2 ± 25.4 |
| ALP (U/L) | 117.9 ± 34.9 | 112.8 ± 42.9 | 104.9 ± 25.5 | 111.5 ± 39.8 | 144 ± 55.6 | 112.3 ± 13.9 |
| TP (mg/dl) | 7.6 ± 0.4 | 8.3 ± 0.8 | 7.9 ± 0.6 | 8.1 ± 0.5 | 8 ± 0.6 | 7.7 ± 0.2 |
| Creatinine (mg/dl) | 0.9 ± 0.1 | 0.9 ± 0 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0 |
| Na (mmol/L) | 134.6 ± 4.9 | 134.4 ± 4.3 | 135.8 ± 5.9 | 135.8 ± 3.2 | 133.6 ± 4 | 135.6 ± 2 |
| K (mmol/L) | 3.5 ± 0.6 | 3.9 ± 0.4 | 3.7 ± 0.6 | 4.1 ± 0.6 | 4.3 ± 0.3 | 4.3 ± 0.2 |
| Cl (mmol/L) | 112.3 ± 2.3 | 105 ± 3.5 | 100 ± 6.1 | 96.5 ± 2.2 | 98.5 ± 4.4 | 101 ± 4.5 |
| FEMALE | ||||||
| ALT (U/L) | 55.3 ± 7.3 | 82.4 ± 24.8 | 59.7 ± 12 | 66.4 ± 17.3 | 50.7 ± 12.8 | 69.1 ± 12.6 |
| AST (U/L) | 155.4 ± 20.1 | 141.2 ± 19.4 | 150.6 ± 15 | 147.2 ± 37.1 | 155.2 ± 25.8 | 143.8 ± 26.4 |
| ALP (U/L) | 104.6 ± 60.3 | 97 ± 60.5 | 93.5 ± 33.3 | 98.4 ± 49.8 | 127.7 ± 42.2 | 121 ± 33.4 |
| TP (mg/dl) | 7.9 ± 0.4 | 7.8 ± 0.5 | 8.2 ± 0.2 | 8.2 ± 0.7 | 7.8 ± 0.4 | 8.4 ± 0.5 |
| Creatinine (mg/dl) | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0 | 0.9 ± 0 | 0.9 ± 0.1 |
| Na (mmol/L) | 133.4 ± 3.1 | 132 ± 4 | 137.4 ± 3.3 | 137.4 ± 2.8 | 132 ± 5.2 | 136.8 ± 5.4 |
| K (mmol/L) | 3.9 ± 0.2 | 4 ± 0.1 | 3.9 ± 0.3 | 3.7 ± 0.8 | 3.4 ± 0.7 | 3.8 ± 0.4 |
| Cl (mmol/L) | 103.2 ± 4.3 | 98.5 ± 4.2 | 95.6 ± 3.5 | 96.6 ± 6.5 | 98.3 ± 3.5 | 98.5 ± 2.4 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; TP, total protein; Na, sodium; K, potassium; Cl, chloride. The values are expressed as mean ± standard deviation. 5 animals/sex/group, unless otherwise specified.