Table 1.
Estimated marginal means of annual change of eGFR according to categories of Dickkopf-3–to-creatinine concentrations in urine in participants of the CARE FOR HOMe Study cohort
| Urinary DKK3 to Creatinine, pg/mg | Annual Change of eGFR, % | 95% CI | P Value | Annual Change of eGFR, ml/min | 95% CI | P Value |
|---|---|---|---|---|---|---|
| Crude | ||||||
| ≤200 | 1.3 | −0.2 to 2.8 | Reference | 0.2 | −0.5 to 0.8 | Reference |
| 201–1000 | −1.5 | −2.6 to −0.4 | <0.01 | −1.2 | −1.7 to −0.7 | 0.002 |
| 1001–4000 | −2.3 | −4.1 to −0.6 | 0.003 | −1.5 | −2.3 to −0.7 | 0.002 |
| >4000 | −8.3 | −11.7 to −5.0 | <0.001 | −2.3 | −3.4 to −1.3 | <0.001 |
| Model 1 | ||||||
| ≤200 | 0.8 | −0.9 to 2.6 | Reference | −0.1 | −0.9 to 0.6 | Reference |
| 201–1000 | −2.1 | −3.5 to −0.7 | 0.004 | −1.5 | −2.2 to −0.9 | 0.002 |
| 1001–4000 | −2.7 | −4.7 to −0.7 | <0.01 | −1.6 | −2.5 to −0.7 | <0.01 |
| >4000 | −9.0 | −12.3 to −5.6 | <0.001 | −2.6 | −3.7 to −1.5 | <0.001 |
| Model 2 | ||||||
| ≤200 | 1.6 | −1.4 to 3.5 | Reference | 0.3 | −0.5 to 1.1 | Reference |
| 201–1000 | −1.7 | −3.2 to −0.3 | 0.001 | −1.3 | −2.0 to −0.6 | <0.001 |
| 1001–4000 | −3.1 | −5.2 to −1.0 | <0.001 | −1.8 | −2.8 to −0.9 | <0.001 |
| >4000 | −11.5 | −15.1 to −8.0 | <0.001 | −4.3 | −5.5 to −3.0 | <0.001 |
| Model 3 | ||||||
| ≤200 | 0.9 | −0.9 to 2.8 | Reference | 0.1 | −0.7 to 0.9 | Reference |
| 201–1000 | −1.7 | −3.1 to −0.3 | <0.01 | −1.3 | −2.0 to −0.6 | 0.002 |
| 1001–4000 | −2.4 | −4.5 to −0.3 | 0.01 | −1.6 | −2.5 to −0.7 | 0.002 |
| >4000 | −7.6 | −10.8 to −4.3 | <0.001 | −2.8 | −4.1 to −1.6 | <0.001 |
Model 1: adjusted for age, sex, body mass index, systolic BP, diabetes, and smoking. Model 2: model 1 adjusted for eGFR. Model 3: model 2 adjusted for log albuminuria. P=0.21 for the interaction between log albuminuria and DKK3 to creatinine. DKK3, Dickkopf-3; 95% CI, 95% confidence interval.