Table 2.

Integrated discrimination improvement and net reclassification improvement by addition of urinary Dickkopf-3 to creatinine to the eight-variable kidney failure risk equation as reported by Tangri et al.²¹ in predicting >0%, >5%, and >10% decreases of eGFR in participants of the CARE FOR HOMe Study

Outcome	IDI	95% CI	P Value	NRI	95% CI	P Value
>0% decrease of eGFR	0.014	0.01 to 0.02	<0.001	0.082	0.02 to 0.14	<0.01
>2% decrease of eGFR	0.009	0.01 to 0.01	<0.001	0.067	0.01 to 0.12	0.02
>5% decrease of eGFR	0.014	0.01 to 0.02	<0.001	0.106	0.06 to 0.16	<0.001
>10% decrease of eGFR	0.013	0.01 to 0.02	<0.001	0.045	0.01 to 0.08	<0.01

IDI, integrated discrimination improvement; 95% CI, 95% confidence interval; NRI, net reclassification improvement.