Table 4.

Associations of folic acid intake with retinal arteriosclerosis.

tHcy	<10 (umol/L)		10–15 (umol/L)		>15 (umol/L)		Overall
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
TOTAL
Unadjusted	1.06 (0.72, 1.56)	0.7655	0.92 (0.70, 1.21)	0.5514	0.72 (0.45, 1.15)	0.1722	0.95 (0.78, 1.16)	0.6197
Model 1	1.07 (0.72, 1.59)	0.7341	0.92 (0.69, 1.22)	0.5591	0.67 (0.41, 1.08)	0.1068	0.93 (0.76, 1.14)	0.4899
Model 2	1.07 (0.72, 1.59)	0.7404	0.93 (0.70, 1.23)	0.6097	0.68 (0.41, 1.08)	0.1085	0.94 (0.76, 1.15)	0.5163
Model 3	1.08 (0.71, 1.66)	0.7270	0.96 (0.71, 1.29)	0.7820	0.63 (0.38, 1.03)	0.0674	0.94 (0.76, 1.17)	0.5917
Model 4	0.97 (0.62, 1.52)	0.9065	0.94 (0.69, 1.27)	0.6732	0.65 (0.39, 1.07)	0.0966	0.92 (0.74, 1.15)	0.4679
Model 5	0.97 (0.61, 1.50)	0.8522	0.93 (0.68, 1.26)	0.6365	0.62 (0.37, 1.03)	0.0699	0.91 (0.73, 1.13)	0.4031
Model 6	0.96 (0.61, 1.50)	0.3605	0.92 (0.67, 1.25)	0.5926	0.64 (0.37, 1.04)	0.0766	0.90 (0.73, 1.13)	0.3700
MALE
Unadjusted	1.53 (0.62, 3.78)	0.3605	1.09 (0.68, 1.74)	0.7210	1.14 (0.61, 2.16)	0.6758	1.20 (0.85, 1.70)	0.2941
Model 1	1.49 (0.57, 3.88)	0.4182	1.06 (0.66, 1.72)	0.8071	1.14 (0.59, 2.20)	0.6991	1.16 (0.82, 1.65)	0.3971
Model 2	1.42 (0.53, 3.81)	0.4804	1.07 (0.66, 1.73)	0.7927	1.13 (0.58, 2.19)	0.7132	1.16 (0.82, 1.64)	0.4136
Model 3	1.33 (0.47, 3.79)	0.5902	1.20 (0.72, 2.00)	0.4802	1.10 (0.54, 2.21)	0.7923	1.20 (0.83, 1.73)	0.3397
Model 4	1.02 (0.31, 3.34)	0.9703	1.24 (0.72, 2.14)	0.4364	1.23 (0.59, 2.56)	0.5746	1.27 (0.87, 1.86)	0.2205
Model 5	1.19 (0.32, 4.41)	0.7948	1.25 (0.72, 2.20)	0.4236	1.17 (0.55, 2.47)	0.6876	1.22 (0.83, 1.80)	0.3088
Model 6	1.04 (0.26, 4.09)	0.9573	1.28 (0.73, 2.26)	0.3891	1.20 (0.56, 2.57)	0.6386	1.23 (0.84, 1.82)	0.2938
FEMALE
Unadjusted	0.98 (0.64, 1.50)	0.9178	0.84 (0.60, 1.19)	0.3276	0.42 (0.20, 0.85)	0.0191	0.84 (0.66, 1.07)	0.1595
Model 1	0.99 (0.64, 1.54)	0.9711	0.84 (0.59, 1.20)	0.3390	0.36 (0.16, 0.74)	0.0076	0.83 (0.64, 1.06)	0.1337
Model 2	1.00 (0.64, 1.56)	0.9962	0.85 (0.60, 1.22)	0.3839	0.35 (0.16, 0.74)	0.0078	0.83 (0.65, 1.07)	0.1494
Model 3	1.06 (0.66, 1.73)	0.7996	0.87 (0.60, 1.26)	0.4528	0.32 (0.14, 0.69)	0.0054	0.83 (0.64, 1.08)	0.1668
Model 4	0.92 (0.55, 1.53)	0.7414	0.82 (0.56, 1.21)	0.3112	0.29 (0.11, 0.66)	0.0051	0.77 (0.59, 1.01)	0.0582
Model 5	0.92 (0.55, 1.54)	0.7553	0.80 (0.54, 1.18)	0.2604	0.28 (0.11, 0.67)	0.0059	0.77 (0.59, 1.01)	0.0596
Model 6	0.92 (0.55, 1.54)	0.7479	0.79 (0.53, 1.16)	0.2293	0.28 (0.11, 0.67)	0.0061	0.77 (0.58, 1.00)	0.0544

Model 1: adjusted for age, SBP, DBP, BMI, WHR, education. Model 2: adjusted for age, SBP, DBP, BMI, WHR, education, smoking, alcohol consumption. Model 3: adjusted for age, SBP, DBP, BMI, WHR, education, smoking, alcohol consumption, PWV, MAP. Model 4: adjusted for age, SBP, DBP, BMI, WHR, education, smoking, alcohol consumption, PWV, MAP, cooking oil, consumption of bean product, consumption of meat, consumption of vegetables and fruits, vitamin supplementation. Model 5: adjusted for age, SBP, DBP, BMI, WHR, education, smoking, alcohol consumption, PWV, MAP, cooking oil, consumption of bean product, consumption of meat, consumption of vegetables and fruits, vitamin supplementation, Uric acid, Creatinine, eGFR, ALP, BUN. Model 6: adjusted for age, SBP, DBP, BMI, WHR, education, smoking, alcohol consumption, PWV, MAP, cooking oil, consumption of bean product, consumption of meat, consumption of vegetables and fruits, vitamin supplementation, Uric acid, Creatinine, eGFR, ALP, BUN, Glucose; Triglycerides, HDL-C.

SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; WHR, Waist-to-Hip Ratio; PWV, pulse wave velocity; MAP, mean arterial pressure; eGFR, estimated glomerular filtration rate; ALP, alkaline phosphatase; BUN, blood urea nitrogen; HDL-C, high-density lipoprotein cholesterol.