Table 3:
Annulus and Leaflet Characteristics
| Marfan (n=27) | Control (n=27) | p | ||||
|---|---|---|---|---|---|---|
| 2D Annulus | ||||||
| Lateral diameter (cm) | 3.5 | (3.0–3.8) | 3.1 | (2.6–3.5) | <0.001 | |
| Lateral diameter z-score | 2.7 | (1.2–4.2) | 0.3 | (−0.4–1.0) | <0.001 | |
| A-P diameter (cm) | 2.9 | (2.7–3.4) | 2.7 | (2.3–3.2) | 0.05 | |
| A-P z-score | 1.8 | (0.6–2.8) | 1.2 | (0.7–1.7) | 0.12 | |
| Area (2D; cm2) | 8.2 | (6.3–9.5) | 7.5 | (4.6–8.5) | 0.10 | |
| 3D Annulus | ||||||
| A-P diameter (cm/M) | 2.8 | (2.4–3.3) | 2.6 | (2.4–2.8) | 0.12 | |
| AL-PM diameter (cm/M) | 3.2 | (2.8–3.6) | 2.6 | (2.4–2.8) | 0.007 | |
| Width at commissure (cm/M) | 3.2 | (2.7–3.5) | 2.9 | (2.6–3.0) | 0.007 | |
| Circumference (cm/M) | 10.2 | (8.9–11.3) | 9.3 | (8.3–9.8) | 0.02 | |
| Area (3D; cm2/M2) | 7.7 | (5.8–9.1) | 6.5 | (5.1–7.2) | 0.02 | |
| Annular height (cm/M) | 0.6 | (0.5–0.8) | 0.7 | (0.6–0.8) | 0.046 | |
| AHCWR | 20 | (14–23) | 24 | (22–27) | <0.001 | |
| Non-planar angle (˚) | 149 | (139–158) | 138 | (132–146) | 0.006 | |
| Sphericity | 0.89 | (0.80–0.93) | 0.93 | (0.90–0.97) | 0.049 | |
| 3D Leaflets | ||||||
| Total area (cm2/M2) | 8.1 | (6.4–9.9) | 7.7 | (6.4–8.1) | 0.15 | |
| Anterior area (cm2/M2) | 4.8 | (4.0–5.3) | 4.3 | (3.7–4.8) | 0.10 | |
| Posterior area (cm2/M2) | 3.5 | (2.4–5.1) | 3.3 | (2.6–3.6) | 0.24 | |
| Anterior length (cm/M) | 2.1 | (1.8–2.2) | 2.2 | (2.0–2.3) | 0.08 | |
| Posterior length (cm/M) | 1.1 | (0.9–1.4) | 1.0 | (0.9–1.1) | 0.30 | |
| Tenting height (mm/M) | 3.5 | (2.0–4.9) | 6.7 | (6.1–7.3) | <0.001 | |
| Tenting area (cm2/M2) | 0.6 | (0.2–0.8) | 1.1 | (0.9–1.2) | <0.001 | |
| Billow volume (cc/M2) | 0.09 | (0.03–0.37) | 0.01 | (0.00–0.02) | <0.001 | |
| Tenting volume (cc)/M2) | 0.67 | (0.21–0.96) | 1.49 | (0.87–1.72) | <0.001 | |
Values are listed as median (IQR). P values calculated by Wilcoxon rank sum test, Two sided P > |Z|
A-P: Anterior-Posterior, AL-PM: Anterolateral-Posteromedial
AHCWR: Annular height to commissural width ratio, BSA: Body Surface Area