Table 3.

Study Measures

Measure	Description of measure	Respondent	Time point administered
			T1	T2	T3
Screening and background measures
Sickle Cell Pain Burden Interview	Screen for SCD pain burden in the past month in six domains (pain, sleep, school, social, emotional, and function).	Youth, Caregiver	✓	✓	✓
Background questionnaire	Report on sociodemographic variables (including family income), as well as access, use, and comfort with smartphones and internet technology.	Youth, Caregiver	✓
Treatment expectancies questionnaire	Rate youth/caregivers expectations that the program will be useful and helpful.	Youth, Caregiver	✓
Adolescent Sleep Wake Scale: Insomnia	Two items used to screen for insomnia symptoms in the past month. Used to screen for delivering the optional website module on insomnia.	Youth	✓
Primary outcome measures
Coping Strategies Questionnaire for Sickle Cell Disease	Measure use of different strategies to cope with pain.	Youth	✓	✓	✓
Daily pain diary (7 day)	Assess daily pain intensity (NRS-11), location, activity limitations, and mood. Completed daily for 7 days.	Youth	✓	✓	✓
Secondary outcome measures
Treatment Evaluation Inventory	Assess perceptions and acceptability of the intervention.	Youth, Caregiver		✓
Patient’s Global Impression of Change Scale	Assess perception of overall improvements since beginning the intervention.	Youth		✓	✓
PROMIS Pediatric Profile	Assess physical and emotional functioning including depressive symptoms, anxiety, mobility, pain interference, fatigue, and peer relationships in the past week. Depressive symptoms scale used to screen for delivering the optional website module on negative emotion.	Youth	✓	✓	✓
Adult Responses to Child Symptoms	Assess caregiver response to youth pain behavior including protectiveness, minimizing, and encouraging.	Caregiver	✓	✓	✓
Bath Adolescent Pain Questionnaire	Caregiver report of youth social functioning, physical functioning, depression, general anxiety, pain specific anxiety, development and femily functioning in the past two weeks.	Caregiver	✓	✓	✓
Client Service Receipt Inventory	C ollect youth’s use of various health services (e.g., outpatient visits, emergency room visits, medications) over the past 6 months.	Caregiver	✓		✓
Symptom Checklist 90	Assess caregiver psychological symptoms including obsessive compulsive, depression, and anxiety during the past week.	Caregiver	✓	✓	✓
Process measures (mediators)
iCanCope program usage	App and website usage (e.g., number of logins, activity) at user leveL	Youth, Caregiver	✓	✓	✓
Multidimens io nal Scale of Perceived Social Support	Assess social support from femily, friends, and significant others.	Youth	✓	✓	✓
Patient Activation Measure	Assesses ability to self-manage health within the context of knowledge, skills, and confidence.	Youth	✓	✓	✓
Sickle Cell Self-Efficacy Scale	Measure disease-specific perceptions of self- efficacy.	Youth	✓	✓	✓
Behavior Rating Inventory of Executive Function	Report frequency of youth’s problem behaviors associated with executive function in the past 6 months.	Caregiver	✓