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. Author manuscript; available in PMC: 2018 Nov 6.
Published in final edited form as: Cell Rep. 2018 Sep 18;24(12):3251–3261. doi: 10.1016/j.celrep.2018.08.065

Figure 3. HLTF Contributes to Fork Degradation in FANCJ-KO Cells, and FANCJ Contributes to Fork Degradation in HLTF-Depleted Cells following Prolonged Stress.

Figure 3.

(A) Western blot analysis with the indicated Abs of lysates from control and FANCJ-KO 293T cells expressing shRNA against HLTF or NSC.

(B) Schematic, representative images, and quantification of the CldU/IdU ratio after HU treatment. (C) Schematic, representative images, and quantification of the CIdU tract length.

Each dot represents one fiber; at least 200 fibers are quantified from two independent experiments. Red bars represent the median. Statistical analysis according to two-tailed Mann-Whitney test; ****p < 0.0001.