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. 2018 Oct 30;9:1236. doi: 10.3389/fphar.2018.01236

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Copyright © 2018 Ji, Yang, Cai, Lei, Wang, Gupta, Teng, Chen, Kong and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemical structure of VS-4718 and concentration-dependent viability curves for parental and ABCB1-overexpressing cells incubated with VS-4718. (A) Chemical structure of VS-4718. (B) Concentration-viability curves for KB-3-1 and KB-C2 cells incubated with VS-4718 for 72 h. (C) Concentration-viability curves for SW620 and SW620/Ad300 cells incubated with VS-4718 for 72 h. (D) Concentration-viability curves for HEK293/pcDNA3.1 and HEK293/ABCB1 cells incubated with VS-4718 for 72 h. The cell viability was determined by MTT assay. Data are expressed as mean ± SD, and representative of three independent experiments in triplicate are shown.