Fig. 6.

Sex-specific fat mass gain and/or redistribution on chow vs. HFD. Column bar graphs showing fat mass gain over 8 weeks on chow vs. HFD consumption in male and female mice. Four types of fat mass—gonadal (epididymal/ovarian), mesenteric, perirenal, and brown—were assessed. a Diet did not change gonadal fat depots in male mice. b HFD-fed WT and Crhr2^−/− male mice increased their mesenteric fat depots by 53.79% and 145.75%, respectively compared with WT chow-fed controls. c HFD-fed WT male mice increased their perirenal fat depots by 32.67% vs. chow. d HFD-fed male Crhr2^−/− mice increased their brown fat depots by 253.1% compared with chow-fed WT mice. e HFD-fed female Crhr2^−/− mice gained 103.91% more ovarian fat vs. chow diet. f HFD-fed female Crhr2^−/− mice increased their mesenteric fat depots by 38% vs. chow. g HFD-fed female Crhr2^−/− mice increased their perirenal fat mass by 140% vs. chow diet and by ~ 59% compared with HFD-fed WT female mice. h HFD-fed female Crhr2^−/− mice increased their brown fat depots by 60.86% vs. chow controls. n = 5/group/sex. Three-way ANOVA and post hoc Tukey’s multiple comparisons