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. 2018 Nov 6;18:186. doi: 10.1186/s12883-018-1179-0

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Change of EDSS between baseline and visit 3, at 12 months vs number of 12-month pre-treatment relapses (n = 47) (a) and 12-month post-treatment relapses (n = 47) (b). The size of the bubbles represents the number of observations at each point on the graph