Table 2.

Univariable and multivariable Cox regression analysis of overall survival

		univariable analysis		multivariable analysis
		HR (95% CI)	P	HR (95% CI)	P
Age	per 10 years older	1.32 (1.03–1.69)	0.026*
Gender	male (vs. female)	1.17 (0.61–2.25)	0.639
Smoking status	never smoker (vs. current/past)	0.66 (0.20–2.19)	0.492
Karnofsky Performance Status	per 10 higher	0.76 (0.62–0.92)	0.005*	0.76 (0.62–0.98)	0.030*
UICC stage	IVA-B (vs. I-III)	1.87 (1.01–3.47)	0.045*
Tumor grade	G3 (vs. G1-G2)	0.91 (0.54–1.54)	0.731
Hemoglobin	per 1 g/dL higher	0.89 (0.77–1.04)	0.143
log NLR	per 1 log NLR higher	1.81 (1.16–2.81)	0.009*	1.58 (1.01–2.47)	0.043*
log PLR	per 1 log PLR higher	1.62 (0.99–2.63)	0.054

CI confidence interval, G tumor grade, HR hazard ratio, log NLR natural logarithm of neutrophil-to-lymphocyte ratio, log PLR natural logarithm of platelet-to-lymphocyte ratio, UICC Union for International Cancer Control; *statistically significant