Table 3.

Univariable Cox regression analysis of recurrence

		Univariable analysis
		HR (95% CI)	P
Loco-regional recurrence (38 events)
Age	per 10 years older	1.08 (0.80–1.48)	0.607
Gender	male vs. female	1.21 (0.53–2.75)	0.648
Smoking status	never smoker (vs. current/past)	1.68 (0.34–8.31)	0.526
Karnofsky Performance Status	KPS over 70	0.55 (0.23–1.35)	0.191
UICC stage	IVA-B (vs. I-III)	3.43 (1.34–8.78)	0.010*
Tumor grade	G3 (vs. G1-G2)	0.78 (0.40–1.53)	0.477
Hemoglobin	per 1 g/dL higher	0.92 (0.76–1.13)	0.424
log NLR	per 1 log NLR higher	1.49 (0.83–2.68)	0.182
log PLR	per 1 log PLR higher	1.65 (0.88–3.10)	0.117
Distant recurrence (20 events)
Age	per 10 years older	0.77 (0.49–1.22)	0.272
Gender	male	2.48 (0.57–10.7)	0.224
Smoking status	never smoker (vs. current/past)	0.04 (0.00–22.86)	0.314
Karnofsky Performance Status	KPS over 70	2.53 (0.34–18.94)	0.367
UICC stage	IV (vs. I-III)	9.91 (1.33–74.03)	0.025*
Tumor grade	G3 (vs. lower)	1.53 (0.64–3.68)	0.342
Hemoglobin	per 1 g/dL higher	1.11 (0.84–1.46)	0.472
log NLR	per 1 log NLR higher	1.38 (0.65–2.91)	0.400
log PLR	per 1 log PLR higher	1.44 (0.65–3.22)	0.371
Any recurrence (46 events)
Age	per 10 years older	1.04 (0.78–1.28)	0.779
Gender	male	1.30 (0.61–2.79)	0.501
Smoking status	never smoker (vs. current/past)	0.60 (014–2.63)	0.501
Karnofsky Performance Status	KPS over 70	0.74 (0.33–1.65)	0.457
Localization	larynx or hypopharynx (vs. other)	1.24 (0.66–2.33)	0.497
UICC stage	IV (vs. I-III)	3.49 (1.48–8.24)	0.004*
Tumor grade	G3 (vs. G1-G2)	0.96 (0.53–1.74)	0.891
Hemoglobin	per 1 g/dL higher	0.95 (0.79–1.14)	0.948
log NLR	per 1 log NLR higher	1.49 (0.88–2.53)	0.134
log PLR	per 1 log PLR higher	1.55 (0.88–2.74)	0.128

CI confidence interval, G tumor grade, HR hazard ratio, log NLR natural logarithm of neutrophil-to-lymphocyte ratio, log PLR natural logarithm of platelet-to-lymphocyte ratio, UICC Union for International Cancer Control; *statistically significant