Table 1.

Neurologic toxicity of plasmocid in different animal species [1]

Species	Minimum lethal daily dose (mg/kg/day)/Minimum cumulative dose causing neurologic signs or lesions (mg/kg)a	Human equivalent doses based on body surface area (mg/kg)b
Rhesus monkeys	4.5/3	1.4/0.96
Cynomolgus monkeys	< 3/6	< 0.96/1.9
Sooty Mangabey monkeys	24/72	7.7/23
Dogs	3/9	1.7/5
Rats	24/196	3.9/32
Mice	72/144	5.9/12

^aDoses administered as three equal divided doses daily until animals succumbed or were sacrificed

^bCalculated according to FDA recommendations [21]