Table 2.

The correlation of clinicopathological variables with VEGFR2 and intratumoral MVD in primary tumors

Variables	Cases (N)	VEGFR2 immunoreactivity				Intratumoral MVD
		Low	High	χ2	P-value	Low ≤28	High >28	χ2	P-value
Age, years				1.770	0.183			0.068	0.794
≤58	68	29	39			28	40
>58	49	27	22			19	30
Sex				0.139	0.710			0.948	0.330
Male	71	33	38			26	45
Female	46	23	23			21	25
Tumor length (cm)				0.513	0.774			1.215	0.545
<3	38	20	18			18	20
3–5	57	26	31			21	36
>5	22	10	12			8	14
Differentiation				1.437	0.487			1.428	0.490
Well	31	12	19			15	16
Moderate	67	34	33			24	43
Poor	19	10	9			8	11
Depth of invasion				3.217	0.073			6.540	0.011*
T1+T2	76	41	35			37	39
T3+T4	41	15	26			10	31
Lymph node metastasis				6.042	0.014*			11.963	0.001*
pN−	45	28	17			27	18
pN+	72	28	44			20	52
Stage				4.811	0.028*			6.835	0.009*
I+II	65	37	28			33	32
III	52	19	33			14	38

Note:

^*P<0.05.

Abbreviations: MVD, microvessel density; pN−, no lymph node metastasis; pN+, lymph node metastasis; VEGFR2, vascular endothelial growth factor receptor 2.