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In Silico Protein Modeling. a Wild-type BRAF kinase domain. Cyan indicates αC helix; gold, activation loop. Residues affected by novel indel are colored according to type of atom. b Normal activation mechanism of wild-type BRAF protein. c BRAF V600E constitutively active variant. d Novel BRAF indel with changes to numerous amino acids in the kinase domain activation loop, consistent with a kinase-active conformation
