Table 1.

Published cases of reactions to oral vancomycin

Reference	Sex	Age	Reaction	Vancomycin dose, treatment duration before rash	Vancomycin serum level	Risk factors
Bailey et al. [2]	M	82	Red man syndrome	250 mg every 6 h, 4 days	Not done	Acute on chronic kidney disease, high vancomycin dose
Baumgartner et al. [3]	M	51	Maculopapular rash	125 mg every 6 h, 3 days	Not done	Diverticulitis, severe CDI
Bergeron et al. [4]	M	23 months	Red man syndrome	90 mg every 6 h, first day	28.7 mcg/mL	Multiple drug hypersensitivities
Bossé et al. [5]	M	35	Anaphylaxis	500 mg, first dose	Not done	Cystic fibrosis, multiple hypersensitivities-IV vancomycin hypersensitivity, severe CDI
Choudhry et al. [6]	F	60	Linear IgA bullous dermatosis	Unknown dose, 14 days	Not reported	Prolonged duration of treatment
Killian et al. [7]	F	67	Red man syndrome	500 mg every 6 h, first day	4.1 mcg/mL	High vancomycin dose
McCullough et al. [8]	F	82	Maculopapular rash	125 mg every 6 h, 8 days	Not done	Chronic kidney disease
Mizumura et al. [9]	M	76	Maculopapular Rash	500 mg every 6 h, 9 days	3.9 mcg/mL	High vancomycin dose, severe CDI
Nallasivan et al. [10]	M	58	Red man syndrome	Dose not reported, 3 days	Not done	Acute kidney injury requiring dialysis, ICU care
O’Brien et al. [11]	M	45	Linear IgA bullous dermatosis	Unknown dose, 2 days	Not reported	End stage renal failure
Osawa et al. [12]	F	73	Maculopapular rash	250 mg, first day after completing oral desensitization	Not done	IV vancomycin hypersensitivity, recent colon perforation
Current report	F	66	Maculopapular rash	125 mg every 6 h, 4 days	0.1 mcg/mL

CDI, Clostridium difficile infection; d, days; f, female; h, hour; m, Male