Table 2.
Genes included in the RNA-Seq panel
| Gene | Function |
|---|---|
| TNF | This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation |
| CASP3 | Is a member of the cysteine-aspartic acid protease (caspase) family; plays a central role in the execution phase of cell apoptosis |
| CASP7 | Is a member of the cysteine-aspartic acid protease (caspase) family; plays a central role in the execution phase of cell apoptosis/inflammation |
| CASP8 | Is a member of the cysteine-aspartic acid protease (caspase) family; plays a central role in the execution phase of cell apoptosis |
| CASP10 | Is a member of the cysteine-aspartic acid protease (caspase) family; plays a central role in the execution phase of cell apoptosis |
| BAX | BCL2-associated X protein, act as anti- or pro-apoptotic regulator that is involved in a wide variety of cellular activities |
| TNFRSF1A | Is one of the major receptors for the tumor necrosis factor-α; can activate NF-κB, mediate apoptosis, and function as a regulator of inflammation |
| TXN | Thioredoxin; inhibits oxidative stress and caspase 3 activity |
| BCL2 | Encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death |
| POMC | One peptide produced from the POMC protein is α-MSH involved in regulating the pigment-producing cells of the skin and hair (melanocytes), where it binds to melanocortin 1 receptor (MC1R)/inflammation |
| MC1R | Controls melanogenesis/inflammation inhibitor |
| MC4R | Encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins/inflammation inhibitor |
| TPT1 | Microtubule stabilization/inflammation |
| FASLG | Fas ligand (TNF superfamily, member 6); induction of apoptosis triggered by binding to FAS |
| BCL3 | Involved in regulation of cell proliferation and contributes to transcriptional regulation of NFKB. Pro-survival and pro-inflammatory |
| NFKB1 | Inflammation/cell damage. Nuclear Factor Kappa B Subunit 1; is a transcription regulator which stimulates the expression of genes involved in a wide variety of biological function |
| TYRP1 | Encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Inflammation |
| DCT | Regulating eumelanin and phaeomelanin levels/inflammation |
| MLANA | Involved in melanosome biogenesis/oxidative stress |
| WNT7A | Wnt Family Member 7A, implicated in oncogenesis and in several developmental processes. Hair growth/inflammation inhibitor |
| MITF | Involved in melanocyte survival, controls the expression of genes related to melanin synthesis. Cell differentiation, proliferation, and survival/inflammation |
| MAPK1 | Mitogen-activated protein kinase 1, involved in cell proliferation and differentiation/inflammation |
| CAPN3 | Intracellular protease/activated in apoptotic cells |
| CFLAR | Is a regulator of apoptosis and is structurally similar to caspase-8/apoptosis inhibitor |
| CCBL2 | Cysteine conjugate-beta lyase 2, involved in the regulation of oxidative stress/inflammation |
| CDC5L | Cell cycle control/inflammation |
| CSNK1G3 | WNT signaling/inflammation |
| PHACTR2 | Phosphatase and actin regulator 2/inflammatory cytokine in dermal cells |
| GGT1 | Involved in maintenance of intracellular GSH level. It is part of the cellular antioxidant defense mechanism/inflammation |
| GAPDH | Glyceraldehyde-3-phosphate dehydrogenase. Endogenous control/constitutive expression. |
| GPD1 | Glycerol-3-phosphate dehydrogenase 1, involved in the redox metabolism |
| GAPDH | Glyceraldehyde-3-phosphate dehydrogenase. Endogenous control/constitutive expression |
The function of the genes was extracted from: GeneCards Human Gene Database and UCSC Genome-Browser.