Table 2.
Association between baseline white blood cell count and total mortality and coronary heart disease (CHD) mortality in the Guangzhou Biobank Cohort Study, 2003–2016
| Decile of WBC count, ×109/L (range) | Age, sex-adjusted results (n = 29,925) | Multivariable adjusteda (n = 29,925) | Further excluding deaths within 2 yearsa (n = 29,672) | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Total mortality (no. of deaths = 2997) | ||||||
| 1st decile (f < 4.5; m < 4.7) | 1.36 (1.14, 1.63) | 0.001 | 1.31 (1.09, 1.58) | 0.005 | 1.20 (0.99, 1.46) | 0.07 |
| 2nd decile (f 4.5–4.8; m 4.7–5.2) | 1.32 (1.10, 1.58) | 0.003 | 1.33 (1.10, 1.60) | 0.003 | 1.26 (1.04, 1.53) | 0.02 |
| 3rd decile (f 4.9–5.3; m 5.3–5.7) | 1.06 (0.88, 1.28) | 0.51 | 1.05 (0.87, 1.27) | 0.63 | 0.97 (0.80, 1.18) | 0.77 |
| 4th decile (f 5.4–5.6; m 5.8–6.0) | Reference | Reference | Reference | |||
| 5th decile (f 5.7–6.0; m 6.1–.4) | 1.30 (1.09, 1.54) | 0.004 | 1.29 (1.08, 1.55) | 0.005 | 1.21 (1.00, 1.46) | 0.04 |
| 6th decile (f 6.1–6.3; m 6.5–6.8) | 1.13 (0.94, 1.37) | 0.20 | 1.14 (0.94, 1.38) | 0.20 | 1.09 (0.90, 1.34) | 0.38 |
| 7th decile (f 6.4–6.8; m 6.9–7.2) | 1.36 (1.14, 1.62) | 0.001 | 1.36 (1.13, 1.63) | 0.001 | 1.28 (1.06, 1.53) | 0.009 |
| 8th decile (f 6.9–7.3; m 7.3–7.8) | 1.56 (1.31, 1.85) | < 0.001 | 1.50 (1.26, 1.79) | < 0.001 | 1.41 (1.17, 1.69) | < 0.001 |
| 9th decile (f 7.4–8.2; m 7.9–8.7) | 1.68 (1.42, 1.99) | < 0.001 | 1.58 (1.32, 1.88) | < 0.001 | 1.48 (1.23, 1.77) | < 0.001 |
| 10th decile (f > 8.2; m > 8.8) | 1.96 (1.66, 2.31) | < 0.001 | 1.83 (1.54, 2.17) | < 0.001 | 1.72 (1.44, 2.05) | < 0.001 |
| CHD mortality (no. of deaths = 459)b | ||||||
| 1st decile (f < 4.5; m < 4.7) | 1.48 (0.85, 2.57) | 0.16 | 1.54 (0.87, 2.71) | 0.14 | 1.48 (0.84, 2.61) | 0.18 |
| 2nd decile (f 4.5–4.8; m 4.7–5.2) | 1.20 (0.67, 2.15) | 0.55 | 1.28 (0.70, 2.31) | 0.42 | 1.22 (0.67, 2.22) | 0.52 |
| 3rd decile (f 4.9–5.3; m 5.3–5.7) | 1.47 (0.86, 2.52) | 0.16 | 1.40 (0.80, 2.44) | 0.24 | 1.40 (0.80, 2.43) | 0.24 |
| 4th decile (f 5.4–5.6; m 5.8–6.0) | Reference | Reference | Reference | |||
| 5th decile (f 5.7–6.0; m 6.1–.4) | 1.51 (0.89, 2.57) | 0.13 | 1.48 (0.86, 2.55) | 0.16 | 1.34 (0.77, 2.34) | 0.30 |
| 6th decile (f 6.1–6.3; m 6.5–6.8) | 1.58 (0.91, 2.74) | 0.11 | 1.58 (0.90, 2.78) | 0.11 | 1.60 (0.91, 2.81) | 0.10 |
| 7th decile (f 6.4–6.8; m 6.9–7.2) | 1.85 (1.11, 3.10) | 0.02 | 1.78 (1.05, 3.02) | 0.03 | 1.74 (1.02, 2.95) | 0.04 |
| 8th decile (f 6.9–7.3; m 7.3–7.8) | 2.40 (1.46, 3.95) | 0.001 | 2.27 (1.36, 3.78) | 0.002 | 2.13 (1.27, 3.56) | 0.004 |
| 9th decile (f 7.4–8.2; m 7.9–8.7) | 1.74 (1.03, 2.93) | 0.04 | 1.62 (0.95, 2.78) | 0.08 | 1.56 (0.90, 2.68) | 0.11 |
| 10th decile (f > 8.2; m > 8.8) | 3.45 (2.15, 5.55) | < 0.001 | 3.02 (1.84, 4.98) | < 0.001 | 2.86 (1.73, 4.73) | < 0.001 |
a adjusted for age, sex, education, occupation, smoking status, alcohol use, physical activity, self-rated health, body mass index, diabetes, triglycerides, high-density lipoprotein cholesterol, platelet count and haemoglobin
b 1528 participant with vascular disease at baseline including coronary heart disease, stroke, angina, myocardial infarction and peripheral vascular disease were excluded