Table 3.
Association between the baseline white blood cell count and cancer and respiratory disease mortality in the Guangzhou Biobank Cohort Study, 2003–2016
| Decile of WBC count, ×109/L (range) | Age, sex-adjusted results (n = 29,925) | Multivariable adjusteda (n = 29,925) | Further excluding deaths within 2 yearsa (n = 29,672) | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Cancer mortality (no. of deaths = 1153) | ||||||
| 1st decile (f < 4. 5; m < 4.7) | 1.33 (1.01, 1.75) | 0.04 | 1.33 (1.00, 1.77) | 0.05 | 1.29 (0.95, 1.75) | 0.10 |
| 2nd decile (f 4.5–4.8; m 4.7–5.2) | 1.50 (1.15, 1.97) | 0.003 | 1.54 (1.17, 2.03) | 0.002 | 1.52 (1.14, 2.03) | 0.005 |
| 3rd decile (f 4.9–5.3; m 5.3–5.7) | Reference | Reference | Reference | |||
| 4th decile (f 5.4–5.6; m 5.8–6.0) | 1.05 (0.79, 1.40) | 0.74 | 1.05 (0.78, 1.41) | 0.75 | 1.10 (0.81, 1.50) | 0.52 |
| 5th decile (f 5.7–6.0; m 6.1–.4) | 1.23 (0.94, 1.61) | 0.13 | 1.20 (0.91, 1.58) | 0.20 | 1.19 (0.89, 1.58) | 0.25 |
| 6th decile (f 6.1–6.3; m 6.5–6.8) | 1.02 (0.76, 1.37) | 0.91 | 1.03 (0.76, 1.39) | 0.86 | 0.99 (0.72, 1.36) | 0.94 |
| 7th decile (f 6.4–6.8; m 6.9–7.2) | 1.15 (0.88, 1.52) | 0.30 | 1.14 (0.86, 1.51) | 0.35 | 1.11 (0.83, 1.49) | 0.49 |
| 8th decile (f 6.9–7.3; m 7.3–7.8) | 1.37 (1.05, 1.78) | 0.02 | 1.30 (0.99, 1.71) | 0.06 | 1.28 (0.96, 1.70) | 0.10 |
| 9th decile (f 7.4–8.2; m 7.9–8.7) | 1.36 (1.04, 1.77) | 0.02 | 1.24 (0.94, 1.63) | 0.14 | 1.25 (0.94, 1.67) | 0.13 |
| 10th decile (f > 8.2; m > 8.8) | 1.27 (0.97, 1.66) | 0.09 | 1.13 (0.85, 1.50) | 0.41 | 1.13 (0.84, 1.52) | 0.42 |
| Respiratory disease mortality (no. of deaths = 325) | ||||||
| 1st decile (f < 4. 5; m < 4.7) | 1.23 (0.69, 2.19) | 0.49 | 1.09 (0.59, 1.99) | 0.78 | 1.16 (0.62, 2.17) | 0.64 |
| 2nd decile (f 4.5–4.8; m 4.7–5.2) | 1.19 (0.66, 2.14) | 0.55 | 1.23 (0.68, 2.22) | 0.50 | 1.30 (0.70, 2.40) | 0.41 |
| 3rd decile (f 4.9–5.3; m 5.3–5.7) | Reference | Reference | Reference | |||
| 4th decile (f 5.4–5.6; m 5.8–6.0) | 1.36 (0.78, 2.37) | 0.28 | 1.41 (0.80, 2.50) | 0.24 | 1.55 (0.86, 2.79) | 0.15 |
| 5th decile (f 5.7–6.0; m 6.1–.4) | 1.44 (0.84, 2.47) | 0.19 | 1.52 (0.87, 2.64) | 0.14 | 1.50 (0.83, 2.68) | 0.18 |
| 6th decile (f 6.1–6.3; m 6.5–6.8) | 1.41 (0.80, 2.49) | 0.23 | 1.47 (0.82, 2.65) | 0.20 | 1.61 (0.88, 2.95) | 0.12 |
| 7th decile (f 6.4–6.8; m 6.9–7.2) | 1.47 (0.85, 2.52) | 0.17 | 1.55 (0.89, 2.72) | 0.12 | 1.53 (0.85, 2.76) | 0.16 |
| 8th decile (f 6.9–7.3; m 7.3–7.8) | 2.07 (1.24, 3.45) | 0.005 | 2.19 (1.29, 3.72) | 0.004 | 2.28 (1.31, 3.95) | 0.003 |
| 9th decile (f 7.4–8.2; m 7.9–8.7) | 1.99 (1.19, 3.34) | 0.01 | 2.25 (1.32, 3.85) | < 0.001 | 2.26 (1.29, 3.95) | < 0.001 |
| 10th decile (f > 8.2; m > 8.8) | 2.32 (1.41, 3.84) | 0.001 | 2.52 (1.49, 4.27) | 0.001 | 2.51 (1.45, 4.35) | 0.001 |
a adjusted for age, sex, education, occupation, smoking status, alcohol use, physical activity, self-rated health, body mass index, diabetes, triglycerides, high-density lipoprotein cholesterol, platelet count and haemoglobin