Table 4.
Association between the baseline white blood cell count and respiratory disease mortality in the Guangzhou Biobank Cohort Study, 2003–2016, excluding deaths within 2 years
| Decile of WBC count, ×109/L (range) | Multivariable modela (n = 29,672) | Multivariable model in non-smokers a (n = 23,958) | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| 1st decile (f < 4. 5; m < 4.7) | 1.28 (0.68, 2.41) | 0.44 | 1.20 (0.52, 2.80) | 0.67 |
| 2nd decile (f 4.5–4.8; m 4.7–5.2) | 1.21 (0.65, 2.25) | 0.56 | 1.07 (0.45, 2.54) | 0.88 |
| 3rd decile (f 4.9–5.3; m 5.3–5.7) | Reference | Reference | ||
| 4th decile (f 5.4–5.6; m 5.8–6.0) | 1.50 (0.83, 2.72) | 0.18 | 1.51 (0.69, 3.31) | 0.31 |
| 5th decile (f 5.7–6.0; m 6.1–.4) | 1.39 (0.78, 2.51) | 0.27 | 1.45 (0.67, 3.14) | 0.35 |
| 6th decile (f 6.1–6.3; m 6.5–6.8) | 1.49 (0.81, 2.73) | 0.20 | 1.74 (0.79, 3.85) | 0.17 |
| 7th decile (f 6.4–6.8; m 6.9–7.2) | 1.36 (0.75, 2.46) | 0.31 | 1.39 (0.64, 3.03) | 0.40 |
| 8th decile (f 6.9–7.3; m 7.3–7.8) | 1.89 (1.08, 3.31) | 0.03 | 1.91 (0.90, 4.04) | 0.09 |
| 9th decile (f 7.4–8.2; m 7.9–8.7) | 1.99 (1.13, 3.48) | 0.02 | 2.13 (1.01, 4.48) | 0.05 |
| 10th decile (f > 8.2; m > 8.8) | 1.90 (1.08, 3.33) | 0.03 | 1.79 (0.83, 3.84) | 0.14 |
a: adjusted for age, sex, education, occupation, smoking status, alcohol use, physical activity, self-rated health, body mass index, diabetes, triglycerides, high-density lipoprotein cholesterol, platelet count, haemoglobin, force vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and self-reported respiratory disease (COPD, chronic bronchitis, emphysema, asthma, tuberculosis, pneumonia)