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. 2018 Nov 6;10:137. doi: 10.1186/s13148-018-0570-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — TMEM176A suppresses human HCC cell xenograft growth in mice. a Representative tumors from TMEM176A unexpressed and TMEM176A re-expressed LM3 cell xenografts. b Tumor growth curves of TMEM176A unexpressed and TMEM176A re-expressed LM3 cells. ***P < 0.001. c Tumor weights in nude mice at the 24th day after inoculation of unexpressed and TMEM176A re-expressed LM3 cells. Bars: mean of five mice. ***P < 0.001. d Images of hematoxylin and eosin staining show tumors from TMEM176A unexpressed and TMEM176A re-expressed LM3 xenograft mice. IHC staining reveals the expression levels of TMEM176A, MMP2, MMP9, and SAR1A in TMEM176A unexpressed and TMEM176A re-expressed LM3 cell xenografts. Clinical specimens of low and high expression of TMEM176A were stained for SAR1A (× 400)