Table 1.
Baseline characteristics of the matched neoadjuvant and adjuvant radiotherapy cohorts
| Variable | N (%) | Survival | Number of patients (%) | P value | |||||
|---|---|---|---|---|---|---|---|---|---|
| Median (IQR), mo | Adjuvant RT (N = 377) | Neoadjuvant RT (N = 377) | Surgery + Chemotherapy Only (N = 524) |
||||||
| Age, years | 61.03 ± 9.52 | – | 61.88 ± 9.86 | 60.23 ± 9.80 | 61.72 ± 9.04 | 0.0645 | |||
| Sex | 0.9669 | ||||||||
| Male | 719 (56.26) | 58 (18, NR) | 210 | (55.70) | 213 | (56.50) | 296 | (56.49) | |
| Female | 559 (43.74) | 65 (23, NR) | 167 | (44.30) | 164 | (43.50) | 228 | (43.51) | |
| Race | 0.5785 | ||||||||
| White | 1025 (80.20) | 61 (19, NR) | 303 | (80.37) | 309 | (81.96) | 413 | (78.82) | |
| Black | 152 (11.89) | 79 (18, NR) | 47 | (12.47) | 43 | (11.41) | 62 | (11.83) | |
| Other | 101 (7.90) | 57 (26, NR) | 27 | (7.16) | 25 | (6.63) | 49 | (9.35) | |
| Histology | 0.8385 | ||||||||
| Adenocarcinoma | 514 (40.22) | 54 (21, NR) | 144 | (38.20) | 150 | (39.79) | 220 | (41.98) | |
| Squamous cell | 356 (27.86) | 69 (19, NR) | 109 | (28.91) | 104 | (27.59) | 143 | (27.29) | |
| Others | 408 (31.92) | 79 (19, NR) | 124 | (32.89) | 123 | (32.63) | 161 | (30.73) | |
| Grade | 0.0366 | ||||||||
| I/ II | 389 (30.44) | 66 (26, NR) | 101 | (26.79) | 107 | (28.38) | 181 | (34.54) | |
| III/ IV | 738 (57.75) | 48 (17, NR) | 226 | (59.95) | 218 | (57.82) | 294 | (56.11) | |
| Unknown | 151 (11.82) | 103 (35, NR) | 50 | (13.26) | 52 | (13.79) | 49 | (9.35) | |
| T classification | 0.4202 | ||||||||
| T1 | 211 (16.51) | 73 (28, NR) | 70 | (18.57) | 55 | (14.59) | 86 | (16.41) | |
| T2 | 535 (41.86) | 54 (20, NR) | 160 | (42.44) | 148 | (39.26) | 227 | (43.32) | |
| T3 | 155 (12.13) | 46 (15, NR) | 40 | (10.61) | 54 | (14.32) | 61 | (11.64) | |
| T4 | 377 (29.50) | 66 (18, NR) | 107 | (28.38) | 120 | (31.83) | 150 | (28.63) | |
| N classification | 0.2972 | ||||||||
| N0/N1 | 294 (23.00) | 81 (21, NR) | 82 | (21.75) | 80 | (21.22) | 132 | (25.19) | |
| N2/N3 | 984 (77.00) | 56 (19, NR) | 295 | (78.25) | 297 | (78.78) | 392 | (74.81) | |
| Extent of Resection | 0.9712 | ||||||||
| Lobectomy or Bilobectomy | 1056 (82.63) | 64 (21, NR) | 311 | (82.49) | 313 | (83.02) | 432 | (82.44) | |
| Pneumectomy | 222 (17.37) | 53 (15, NR) | 66 | (17.51) | 64 | (16.98) | 92 | (17.56) | |
| Treatment regimen | – | ||||||||
| Neoadjuvant RT | 377 (29.50) | 67 (20, NR) | – | – | – | – | – | – | |
| Adjuvant RT | 377 (29.50) | 61 (17, NR) | – | – | – | – | – | – | |
| Surgery + Chemotherapy Only | 524 (41.00) | 61 (22, NR) | |||||||
NR not reached