Table 3.
Multivariable Cox regression for cancer-specific mortality stratified by T and N stages
| Variable | T1/2 & N2/3 | T3/4 & N0/1 | T3/4 & N2/3 |
|---|---|---|---|
| (N = 746) | (N = 294) | (N = 238) | |
| Age | 1.01 (1.00, 1.02) | 1.00 (0.98, 1.02) | 1.03 (1.01, 1.05) ** |
| Sex | |||
| Male | Ref. | Ref. | Ref. |
| Female | 0.81 (0.66, 1.01) | 0.92 (0.63, 1.34) | 0.97 (0.67, 1.40) |
| Race | |||
| White | Ref. | Ref. | Ref. |
| Black | 0.87 (0.62, 1.21) | 0.80 (0.44, 1.45) | 0.97 (0.57, 1.65) |
| Others | 0.97 (0.68, 1.38) | 1.13 (0.54, 2.34) | 0.88 (0.48, 1.62) |
| Grade | |||
| I/ II | Ref. | Ref. | Ref. |
| III/ IV | 1.34 (1.07, 1.67) * | 1.67 (1.08, 2.58) * | 0.93 (0.63, 1.37) |
| Unknown | 0.74 (0.51, 1.07) | 0.66 (0.30, 1.44) | 1.79 (0.93, 3.46) |
| Histology | |||
| Adenocarcinoma | Ref. | Ref. | Ref. |
| Squamous cell | 1.01 (0.77, 1.31) | 0.69 (0.44, 1.07) | 0.66 (0.42, 1.05) |
| Others | 0.98 (0.77, 1.25) | 0.94 (0.61, 1.44) | 0.72 (0.47, 1.11) |
| Extent of Surgery | |||
| Lobectomy or Bilobectomy | Ref. | Ref. | Ref. |
| Pneumectomy | 1.04 (0.76, 1.43) | 1.00 (0.63, 1.59) | 1.80 (1.25, 2.61) ** |
| Treatment regimen | |||
| Neoadjuvant RT | Ref. | Ref. | Ref. |
| Adjuvant RT | 1.11 (0.84, 1.47) | 1.54 (0.99, 2.38) | 0.74 (0.47, 1.16) |
| Chemotherapy-Only | 1.42 (1.10, 1.83) ** | 0.65 (0.42, 1.02) | 0.93 (0.62, 1.41) |
* p < 0.05; ** p < 0.01