Table 2.
Prevalence of ASD by exposure during a year before delivery date
| Exposure | ASD cases N=2,154 | Pregnancies N=194,494 | Prevalence per 1,000 pregnancies (95% CI) | Crude RR (95% CI) | Adjusted RRa (95% CI) |
|---|---|---|---|---|---|
| Unexposed | 1,500 | 154,107 | 9.7 (9.3–10.2) | 1.00 (reference) | 1.00 (reference) |
| Untreated depression | 196 | 12,994 | 15.1 (13.1–17.3) | 1.55 (1.34–1.80) | 1.49 (1.27–1.75) |
| Treated depression | 446 | 25,778 | 17.3 (15.8–19.0) | 1.78 (1.60–1.98) | 1.70 (1.51–1.92) |
| Other indications for antidepressant use | 12 | 1,615 | 7.4 (4.0–12.6) | 0.76 (0.43–1.35) | 0.73 (0.41–1.29) |
Notes:
a
Adjusted for child sex, maternal BMI, smoking status, parity, anxiety, and other psychiatric disorders.
Abbreviations: ASD, autism spectrum disorder; BMI, body mass index.