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. 2018 Nov 1;13:3625–3634. doi: 10.2147/COPD.S169951

Table S1.

Prognostic value of baseline variables for the percentage of change in PaCO2 after 12 months for the whole group of COPD patients according to the univariate regression model

ΔPaCO2a
nb R2 B 95% CI of B P-value
Age (years) 105 0.042 0.314 0.022 to 0.606 0.035
Gender (F) 105 0.002 −1.057 −6.120 to 4.005 0.680
BMI 99 0.018 0.290 −0.146 to 0.726 0.191
Smoker 105 0.002 −1.340 −7.086 to 4.406 0.645
NIV started after ARF 105 0.055 −6.061 −10.976 to 1.146 0.016
PaO2 (kPa) 102 0.018 −1.127 −2.776 to 0.523 0.178
HCO3− (mmol/L) 102 0.247 −1.426 −1.919 to −0.932 <0.001
FEV1 (% predicted) 99 0.019 0.176 −0.082 to 0.434 0.179
FEV1/FVC (%) 99 0.004 −0.084 −0.347 to 0.179 0.526
RV/TLC (%) 44 0.025 −0.215 −0.631 to 0.202 0.305
Diuretics 105 0.005 1.820 −3.214 to 6.854 0.475
SRI, total score 68 0.110 0.288 0.087 to 0.490 0.006
Comorbid disease
 Obstructive sleep apnea 92 0.007 4.323 −6.622 to 15.268 0.435
 Anxiety 96 0.040 −5.449 −10.941 to 0.044 0.052
 Depression 95 0.038 −5.118 −10.429 to 0.193 0.059
 Diabetes mellitus 102 0.004 −2.083 −8.772 to 4.607 0.538
 Hypertension 97 0.007 2.288 −3.214 to 7.791 0.411
 Coronary artery disease 105 0.015 3.787 −2.114 to 9.688 0.206
 Congestive heart failure 99 0.029 −6.001 −12,993 to 0.890 0.091
NIV settingsc
 IPAP (cmH2O) 103 0.035 −0.638 −1.297 to 0.021 0.058
 EPAP (cmH2O) 103 0.003 −0.421 −1.849 to 1.006 0.560
 BURR (breaths per minute) 103 0.004 −0.292 −1.209 to 0.625 0.529
 Compliance (hours)c 78 0.014 −0.701 −2.048 to 0.647 0.304

Notes:

a

Percentage of change in PaCO2 after 12 months, a negative value indicates a decrease in PaCO2;

b

Number of patients included in the analysis;

c

NIV settings and compliance after 12 months. The values in bold are considered statistically significant (P<0.05).

Abbreviations: ARF, acute respiratory failure; BURR, backup respiratory rate; EPAP, expiratory positive airway pressure; HCO3−, arterial bicarbonate; IPAP, inspiratory positive airway pressure; NIV, noninvasive ventilation; PaCO2, arterial carbon dioxide pressure; PaO2, arterial oxygen pressure; RV, residual volume; SRI, severe respiratory insufficiency questionnaire; TLC, total lung capacity.