Table 2.
Hemodynamic data by right heart catheterization at rest and peak exercise in 93 patients with COPD divided into three groups by mPAP at rest and ΔmPAP/ΔCO slope
| Variable | mPAPrest <25 mmHg
|
mPAPrest ≥25 mmHg | p-value | |
|---|---|---|---|---|
| ΔmPAP/ΔCO slope ≤3 mmHg/L/min | ΔmPAP/ΔCO slope >3 mmHg/L/min | |||
|
n=29 |
n=42 |
n=22 |
||
| mPAP rest, mmHg | 17.9 (3.9) | 18.1 (3.2) | 28.7 (4.6)*,# | <0.001 |
| mPAP peak, mmHg | 33.6 (7.0) | 39.1 (7.1)* | 48.6 (6.7)*,# | <0.001 |
| PAWP rest, mmHg | 9.0 (3.2) | 7.8 (3.4) | 10.7 (2.8)# | 0.01 |
| PAWP peak, mmHg | 16.7 (4.2) | 16.7 (4.1) | 15.8 (3.7) | 0.69 |
| CO rest, L/min | 5.3 (0.8) | 4.9 (1.0) | 5.5 (1.2) | 0.07 |
| CO peak, L/min | 12.3 (1.4) | 9.0 (2.1)* | 9.0 (2.6)* | <0.001 |
| CI rest, L/min/m2 | 2.8 (0.4) | 2.9 (0.4) | 3.1 (0.5)* | 0.04 |
| CI peak, L/min/m2 | 6.4 (0.8) | 5.2 (1.1)* | 5.0 (1.0)* | <0.001 |
| PVR rest, WU | 1.67 (0.57) | 2.19 (0.97) | 3.43 (1.51)*,# | <0.001 |
| PVR peak, WU | 1.38 (0.37) | 2.65 (1.04)* | 3.97 (1.56)*,# | <0.001 |
| TPR rest, WU | 3.4 (0.8) | 3.8 (1.0) | 5.5 (1.6)*,# | <0.001 |
| TPR peak, WU | 2.7 (0.5) | 4.6 (1.3)* | 5.8 (1.8)*,# | <0.001 |
| mRAP rest, mmHg | 5.5 (3.3) | 4.7 (3.2) | 6.9 (3.0)# | 0.03 |
| mRAP peak, mmHg | 9.3 (4.2) | 9.6 (2.4) | 10.7 (3.3) | 0.27 |
| ΔmPAP/ΔCO slope, mmHg/L/min | 2.3 (0.6) | 6.2 (3.5)* | 7.3 (5.0)* | <0.001 |
Notes: ANOVA between the three groups. Values are presented as mean (standard deviation).
*
p<0.05, significantly different from mPAPrest <25 mmHg and ΔmPAP/ΔCO slope ≤3 mmHg/L/min.
#
p<0.05, significantly different from mPAPrest <25 mmHg and ΔmPAP/ΔCO slope >3 mmHg/L/min.
Abbreviations: mPAP, mean pulmonary artery pressure; CO, cardiac output; PAWP, pulmonary arterial wedge pressure; CI, cardiac index; PVR, pulmonary vascular resistance; TPR, total pulmonary resistance; mRAP, mean right atrial pressure.