Table 3.
PAE (h) of linezolid plus fosfomycin exposure for 2 hours against three S. aureus strains
| Strains | LIN
|
FOS
|
LIN + FOS
|
|||
|---|---|---|---|---|---|---|
| 1x MIC | 4x MIC | 1x MIC | 4x MIC | 1+1x MIC | 4+4x MIC | |
|
| ||||||
| No. 36 | 1.39±0.17 | 2.18±0.21 | 1.66±0.34 | 3.02±0.27 | 2.20±0.35 | 3.78±0.45 |
| No. 8 | 2.02±0.28 | 2.23±0.25 | 2.12±0.24 | 2.86±0.33 | 2.82±0.23 | 3.74±0.38 |
| ATCC 25923 | 1.93±0.12 | 2.18±0.16 | 2.53±0.15 | 2.93±0.36 | 2.96±0.23 | 3.84±0.18 |
| Mean ± SD | 1.78±0.34 | 2.20±0.03 | 2.10±0.44 | 2.94±0.08 | 2.66±0.40 | 3.79±0.05 |
Abbreviations: FOS, fosfomycin; LIN, linezolid; MIC, minimum inhibitory concentration; PAE, post-antibiotic effect; S. aureus, Staphylococcus aureus.