Table 4.
PAE (h) of linezolid plus fosfomycin exposure for 3 hours against three S. aureus strains
| Strains | LIN
|
FOS
|
LIN + FOS
|
|||
|---|---|---|---|---|---|---|
| 1x MIC | 4x MIC | 1x MIC | 4x MIC | 1+1x MIC | 4+4x MIC | |
|
| ||||||
| No. 36 | 1.90±0.30 | 2.46±0.31 | 1.85±0.23 | 3.20±0.42 | 3.05±0.38 | 4.18±0.63 |
| No. 8 | 2.08±0.34 | 2.42±0.20 | 2.57±0.26 | 3.16±0.52 | 3.45±0.24 | 4.09±0.45 |
| ATCC 25923 | 2.33±0.21 | 2.31±0.15 | 2.80±0.29 | 3.42±0.56 | 3.30±0.43 | 4.12±0.34 |
| Mean ± SD | 2.10±0.22 | 2.40±0.08 | 2.41±0.50 | 3.26±0.14 | 3.27±0.20 | 4.13±0.05 |
Abbreviations: FOS, fosfomycin; LIN, linezolid; MIC, minimum inhibitory concentration; PAE, post-antibiotic effect; S. aureus, Staphylococcus aureus.