Table 1. . Genes based on genome-wide association study hits.

Gene	Chromosome	Medication	SNP	Number of positive studies (total n)	Number of negative studies
CHRNA5–A3–B4	15	NRT	rs588765	2 (3776)	2
			rs16969968	1 (328)	4
			rs16969968*rs680244	1 (1073)	0
			rs1051730	1 (2633)	3
			rs2036527	1 (1143)	0
			rs680244	0	1
			rs578776	0	5
			rs2229961, rs12914008, rs3813567, rs680244, rs8192475	0	1
		Bupropion	rs16969968*rs680244	1 (1073)	0
			rs16969968, rs578776	0	2
			rs588765, rs2036527, rs2229961, rs1051730, rs12914008, rs3813567, rs680244, rs8192475	0	1
		Varenicline	rs16969968	0	3
			rs578776	0	2
			rs588765, haplotype rs16969968 and rs588765	0	1
		Selegiline	rs3813567	1 (231)	0
			rs680244, rs16969968, rs578776, rs1051730, rs8192475, rs12914008	0	1
CYP2A6	19	NRT	Slow/Fast (genotype-based metric)	1 (709)	0
		Bupropion	Slow/Fast	0	1
CYP2A6-B6		NRT	rs4105144, rs6474412	0	1
		Varenicline	rs4105144, rs6474412	0	1
DBH	9	NRT	1368DBH A	1 (755)	0
			rs77905	0	1
		Bupropion	rs77905	0	1
CHRNA4	20	Varenicline	rs1044396	1 (483)	0k

Table includes only studies with efficacy outcome (abstinence or relapse).

Table includes genes that have GWAS hits and at least one positive gene x drug interaction study.

GWAS: Genome-wide association study; NRP: Nicotine replacement therapy.