Table 2. . Candidate genes.
| Gene | Chromosome | Medication | SNP | Number of positive studies (total n) | Number of negative studies |
|---|---|---|---|---|---|
| COMT | 22 | NRT | Val108/158Met (rs4680) | 2 (991) | 1 |
| Bupropion | rs165599 | 1 (511) | 0 | ||
| rs165599*rs737865 | 1 (511) | 0 | |||
| rs4680, rs737865 | 0 | 1 | |||
| DRD2 | 11 | NRT | Taq1A (rs1800497) | 1 (755) | 2 |
| Taq1B (rs1079597), 141C Ins/Del (rs1799732), Pro319Pro (rs6277), Exon 8 | 0 | 1 | |||
| Bupropion | Taq1A (rs1800497) | 3 (1582) | 3 | ||
| 141C ins/del (rs1799732) | 1 (414) | 0 | |||
| C957T variant, Exon III VNTR | 0 | 1 | |||
| Varenicline | Taq1A (rs1800497) | 0 | 1 | ||
| Venlafaxine | Taq1A (rs1800497) | 0 | 1 | ||
| Taq1B (rs1079597) | 0 | 1 | |||
| Rimonabant | Taq1A (rs1800497) | 1 | 0 | ||
| DRD4 | 11 | NRT | VNTR, C-521T | 0 | 1 |
| Bupropion | Exon III VNTR | 2 (1123) | 1 | ||
| CYP2B6 | 19 | Bupropion | CYP2B6*6 haplotype (rs2279343 + rs3745374) | 1 (326) | 1 |
| CYP2B6*4 (rs2279343) | 1 (478) | 0 | |||
| CYP2B6*5 (rs3211371), CYP2B6*9 (rs3745274) | 0 | 1 | |||
Table includes only studies with efficacy outcome (abstinence or relapse).
Table includes genes that have at least one SNP that has one or more replication studies and total n ≥500.
NRT: Nicotine replacement therapy; VNTR: Variable number of tandem repeat.