Table 3.
Neuropsychiatric Inventory (NPI) Unadjusted and Adjusted Odds Ratios (ORs) by Sex.
| NPIa Domain, no. (%) | Prevalence at Enrollment | Unadjusted | Adjustedb | ||||
|---|---|---|---|---|---|---|---|
| All, n = 186 | Women, n = 85 | Men, n = 101 | Women vs Men | Women vs Men | |||
| OR (95% CI) | P Valuec | OR (95% CI) | P Valuec | ||||
| Delusions | 78 (42%) | 45 (53%) | 33 (33%) | 2.3 (1.3-4.2) | .01 | 2.2 (0.9-5.1) | .07 |
| Hallucinations | 39 (21%) | 19 (22%) | 20 (20%) | 1.2 (0.6-2.4) | .67 | 1.2 (0.4-3.3) | .75 |
| Agitation/aggressionc | 186 (100%) | 85 (100%) | 101 (100%) | – | – | – | – |
| Depression/dysphoria | 95 (51%) | 41 (48%) | 54 (53%) | 0.8 (0.5-1.4) | .48 | 0.7 (0.3-1.7) | .44 |
| Anxiety | 121 (65%) | 62 (73%) | 59 (58%) | 1.9 (1.0-3.6) | .04 | 2.3 (1.0-5.3) | .05 |
| Elation/euphoriad | 13 (7%) | 7 (8%) | 6 (6%) | 1.4 (0.5-4.4) | .54 | – | – |
| Apathy/indifference | 114 (61%) | 45 (53%) | 69 (68%) | 0.5 (0.3-0.9) | .03 | 0.7 (0.3-1.7) | .48 |
| Disinhibition | 95 (51%) | 41 (48%) | 54 (53%) | 0.8 (0.5-1.4) | .48 | 1.1 (0.5-2.8) | .77 |
| Irritability/lability | 157 (84%) | 74 (87%) | 83 (82%) | 1.5 (0.6-3.3) | .36 | 4.4 (1.4-14.1) | .01 |
| Motor disturbance | 96 (52%) | 46 (54%) | 50 (50%) | 1.2 (0.7-2.1) | .53 | 1.2 (0.5-2.9) | .64 |
| Nighttime behaviors | 85 (46%) | 40 (47%) | 45 (45%) | 1.1 (0.6-2.0) | .73 | 0.7 (0.3-1.7) | .48 |
| Appetite/eating | 86 (46%) | 36 (42%) | 50 (50%) | 0.7 (0.4-1.3) | .33 | 0.6 (0.2-1.4) | .23 |
Abbreviation: CI, confidence interval; NPI, Neuropsychiatric Inventory.
a Presence/absence of symptom modeled by logistic regression, test for significance is a Wald χ2.
b Adjusted models are multivariate, including control for all covariates included in Table 1.
c All participants had NPI agitation at baseline due to eligibility criteria.
d Adjusted model not calculated due to small number of events.