Table 1.
Genetic loci associated with PiB-PET with P < 1E-05 in the meta-analysis
| SNP | Chr | Position | A1 | A2 | Gene | Region | PITT | WU | ADNI/IU | Meta | Meta adjusted for APOE*4 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF | Beta | P-value | MAF | Beta | P-value | MAF | Beta | P-value | Beta | P-value | Beta | P-value | |||||||
| rs429358 | 19 | 45411941 | C | T | APOE | Exonic | 0.20 | 0.35 | 5.20E-12 | 0.21 | 0.16 | 5.36E-16 | 0.28 | 0.19 | 7.88E-05 | 0.18 | 9.09E-30 | NA | NA |
| rs13260032 | 8 | 132451455 | C | A | ADCY8,EFR3A | Intergenic | 0.43 | −0.17 | 4.90E-05 | 0.44 | −0.06 | 1.34E-02 | 0.43 | −0.07 | 6.76E-02 | −0.08 | 4.87E-07 | −0.07 | 1.15E-05 |
| rs4680057 | 3 | 153096985 | A | G | RAP2B,C3orf79 | Intergenic | 0.45 | 0.16 | 2.60E-04 | 0.42 | 0.04 | 1.93E-02 | 0.46 | 0.11 | 8.07E-03 | 0.06 | 9.69E-07 | 0.05 | 2.61E-05 |
| rs12908891 | 15 | 64236441 | G | A | DAPK2 | Intronic | 0.46 | 0.12 | 6.38E-03 | 0.49 | 0.06 | 5.77E-06 | 0.50 | 0.01 | 9.01E-01 | 0.06 | 1.39E-06 | 0.04 | 5.30E-04 |
| rs7377304 | 4 | 187129780 | G | T | CYP4V2 | Intronic | 0.42 | 0.08 | 8.84E-02 | 0.46 | 0.06 | 5.98E-05 | 0.47 | 0.09 | 2.83E-02 | 0.06 | 2.46E-06 | 0.06 | 1.59E-05 |
| rs55708341 | 21 | 45627581 | T | A | C21orf33,ICOSLG | Intergenic | 0.23 | 0.18 | 1.88E-04 | 0.18 | 0.05 | 4.65E-03 | 0.19 | 0.07 | 2.26E-01 | 0.07 | 2.51E-06 | 0.06 | 6.74E-05 |
| rs9831119 | 3 | 84712077 | C | T | LINC00971 | ncRNA_intronic | 0.12 | −0.13 | 3.66E-02 | 0.14 | −0.07 | 5.15E-04 | 0.12 | −0.16 | 8.89E-03 | −0.08 | 2.98E-06 | −0.07 | 1.80E-05 |
| rs9531483 | 13 | 84244873 | A | C | SLITRK1 | Intergenic | 0.30 | −0.12 | 7.81E-03 | 0.31 | −0.06 | 5.62E-04 | 0.33 | −0.07 | 1.12E-01 | −0.06 | 3.65E-06 | −0.05 | 8.45E-05 |
| rs6722000 | 2 | 209075957 | G | A | C2orf80,IDH1 | Intergenic | 0.21 | 0.14 | 7.27E-03 | 0.20 | 0.07 | 3.92E-04 | 0.22 | 0.06 | 2.37E-01 | 0.07 | 4.96E-06 | 0.07 | 1.71E-05 |
| rs11923588 | 3 | 184459667 | T | C | MAGEF1,LOC101928992 | Intergenic | 0.07 | −0.20 | 2.19E-02 | 0.06 | −0.19 | 6.50E-05 | 0.06 | −0.14 | 1.53E-01 | −0.18 | 5.66E-06 | −0.13 | 1.56E-03 |
| rs66837203 | 4 | 36897136 | T | C | DTHD1,MIR4801 | Intergenic | 0.06 | 0.24 | 9.85E-03 | 0.08 | 0.10 | 3.53E-04 | 0.04 | 0.13 | 2.36E-01 | 0.11 | 6.03E-06 | 0.09 | 4.66E-04 |
| rs200028958 | 4 | 70923661 | A | G | HTN1 | Intronic | 0.10 | 0.29 | 2.99E-05 | 0.11 | 0.09 | 1.29E-03 | 0.09 | −0.05 | 5.54E-01 | 0.10 | 6.25E-06 | 0.09 | 8.02E-05 |
| rs4526799 | 12 | 57280586 | T | C | HSD17B6,SDR9C7 | Intergenic | 0.34 | −0.19 | 3.58E-05 | 0.34 | −0.04 | 3.09E-02 | 0.36 | −0.04 | 4.18E-01 | −0.05 | 7.26E-06 | −0.06 | 1.16E-06 |
| rs17105538 | 1 | 81315043 | G | A | ELTD1,LPHN2 | Intergenic | 0.13 | 0.13 | 3.65E-02 | 0.15 | 0.08 | 2.08E-04 | 0.17 | 0.09 | 1.10E-01 | 0.08 | 7.66E-06 | 0.07 | 1.58E-05 |
| rs62121100 | 2 | 3093952 | G | T | LINC01250 | ncRNA_intronic | 0.19 | −0.20 | 1.09E-04 | 0.16 | −0.05 | 1.03E-02 | 0.21 | −0.04 | 4.79E-01 | −0.07 | 8.44E-06 | −0.06 | 2.90E-05 |
| rs1809136 | 2 | 11152180 | G | C | KCNF1,FLJ33534 | Intergenic | 0.07 | 0.28 | 5.91E-04 | 0.07 | 0.17 | 5.45E-04 | 0.08 | 0.00 | 9.95E-01 | 0.16 | 9.99E-06 | 0.15 | 6.36E-05 |
A1 minor allele, A2 major allele