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. 2018 Oct 25;26(1):309–321. doi: 10.1038/s41380-018-0246-7

Table 2.

Conditional analysis on SNPs reaching P < 0.05 in the APOE region with additional adjustment for APOE*4 (rs429358) in the meta-analysis

SNP Chr Position A1 A2 Gene Region PITT WU ADNI/IU Meta LD (R2) with
MAF Beta P-value MAF Beta P-value MAF Beta P-value Beta P-value E*4 E*2
rs7412 19 45412079 T C APOE Exonic 0.07 −0.21 7.63E-03 0.07 −0.04 1.45E-01 0.04 −0.06 5.49E-01 −0.06 3.69E-03 0.01 NA
rs3852859 19 45379309 C T PVRL2 Intronic 0.20 0.08 1.14E-01 0.20 0.05 1.10E-01 0.24 0.07 1.52E-01 0.06 8.81E-03 0.004 0.01
rs2075642 19 45377467 A G PVRL2 Intronic 0.20 0.07 1.78E-01 0.20 0.06 8.44E-02 0.22 0.07 1.33E-01 0.06 1.11E-02 0.004 0.01
rs3852856 19 45361574 A G PVRL2 Intronic 0.21 0.06 2.43E-01 0.20 0.07 3.16E-02 0.22 0.06 2.03E-01 0.06 1.15E-02 0.006 0.01
rs75627662 19 45413576 T C APOE Downstream 0.23 −0.15 1.57E-02 0.23 −0.02 2.92E-01 0.26 −0.03 6.19E-01 −0.03 1.50E-02 0.42 0.21
rs4803767 19 45372959 T C PVRL2 Intronic 0.26 0.05 2.63E-01 0.28 0.04 1.56E-01 0.31 0.07 8.34E-02 0.05 2.06E-02 0.002 0.01
rs60389450 19 45372184 C A PVRL2 Intronic 0.26 0.04 3.20E-01 0.26 0.02 1.72E-01 0.31 0.07 8.34E-02 0.03 2.72E-02 0.003 0.01
rs59325138 19 45416291 T C APOE,APOC1 Intergenic 0.38 0.06 2.16E-01 0.36 0.02 2.50E-01 0.36 0.07 1.17E-01 0.03 3.10E-02 0.15 0.03
rs483082 19 45416178 T G APOE,APOC1 Intergenic 0.26 −0.10 1.60E-01 0.29 −0.04 1.59E-01 0.32 −0.06 4.51E-01 −0.05 3.35E-02 0.64 0.16
rs8104483 19 45372354 G T PVRL2 Intronic 0.27 0.03 4.65E-01 0.27 0.02 2.04E-01 0.32 0.09 4.20E-02 0.03 3.67E-02 0.003 0.01
rs3729640 19 45381917 T C PVRL2 UTR3 0.20 0.08 9.33E-02 0.19 0.03 3.35E-01 0.23 0.04 4.33E-01 0.05 3.79E-02 0.004 0.01
rs8104292 19 45372707 A G PVRL2 Intronic 0.27 0.04 4.14E-01 0.28 0.03 2.62E-01 0.32 0.09 4.20E-02 0.04 3.80E-02 0.003 0.01
rs438811 19 45416741 T C APOE,APOC1 Intergenic 0.26 −0.10 1.60E-01 0.30 −0.04 1.84E-01 0.32 −0.06 4.51E-01 −0.04 3.84E-02 0.65 0.16
rs58521715 19 45372129 T A PVRL2 Intronic 0.27 0.03 4.65E-01 0.27 0.02 2.53E-01 0.32 0.09 4.20E-02 0.03 4.50E-02 0.004 0.01

A1 minor allele, A2 major allele