Table 1.

Analysis of ³¹P-MRS-detected metabolic changes following inhibition with MK-2206 in

	PC3
	6 h (5xGI50)	P	12 h (5xGI50)	P	24 h (5xGI50)	P	24 h (3xGI50)	P
PE	62 ± 16	0.008	47 ± 11	0.001	23 ± 16	0.0001	43 ± 26	0.01
PC	74 ± 14	0.02	78 ± 11	0.02	69 ± 13	0.001	71 ± 5	0.0004
GPE	66 ± 34	ns	50 ± 12	0.001	320 ± 104	0.005	153 ± 40	ns
GPC	32 ± 16	0.001	36 ± 11	0.0003	225 ± 63	0.007	121 ± 27	ns
PCr	74 ± 28	ns	54 ± 31	0.04	38 ± 24	0.007	46 ± 24	0.01
NTP	63 ± 17	0.01	56 ± 12	0.002	68 ± 18	0.005	82 ± 11	0.03

	HT29
	24 h (5xGI50)	P
PE	60 ± 9	0.001
PC	67 ± 6	0.0001
GPE	132 ± 26	0.04
GPC	169 ± 31	0.004
PCr	59 ± 8	0.0001
NTP	89 ± 7	0.02

Data are expressed as %T/C and presented as the mean ± SD, n ≥ 4

Two-tailed unpaired t test was used to compare results in treated cells to controls within the same time-point