Table 2.

Survival tables

Predictor	OS hazard ratio	P-value	Adjusted OS hazard ratio	P-value
^aAge (per 10 yrs)	3.64	<0.0001	–	–
^aGrade III (vs. II)	6.61	0.013	–	–
^{a, c}MKI67 exp.	1.58	0.0029	1.12	0.42
NOTCH1 mut.	1.71	0.28	1.10	0.87
^bPIK3 mut.	1.97	0.15	3.11	0.045
RBPJ + NOTCH1 mut.	1.81	0.210	0.85	0.76
^a15q loss	3.52	0.007	1.48	0.47
^{b, c}HES5 exp.	0.82	0.086	0.74	0.024
^{a, c}HEY1 exp.	0.34	0.0009	0.86	0.72
^{a, c}HEY2 exp.	0.35	0.0001	0.79	0.54

	PFS hazard ratio	P-value	Adjusted PFS hazard ratio	P-value
Age (per 10 yrs)	1.12	0.28	–	–
^aGrade III (vs. II)	2.24	0.046	–	–
^cMKI67 exp.	1.04	0.71	0.97	0.81
^aFUBP1 mut.	2.48	0.022	2.14	0.058
NOTCH1 mut.	2.07	0.091	1.52	0.33
PIK3 mut.	1.91	0.11	1.98	0.092
^a RBPJ + NOTCH1 mut.	2.47	0.021	1.86	0.13
^{a, b}14q loss	3.70	0.010	3.90	0.0035
^{a, b, c}HEY1 exp.	0.41	0.0022	0.48	0.018

Cox proportional hazard models for overall survival (OS) and progression-free survival (PFS)

Multivariable OS adjusted for grade and age

Multivariable PFS adjusted for grade

Mut mutation

Exp. expression

^aSignificant on univariate analysis

^bSignificant after covariate adjustment

^cGene expression on a log2 scale, such that the hazard ratio is for each doubling of gene expression