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. 2018 Nov 6;8:16390. doi: 10.1038/s41598-018-34566-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Design and fabrication of MSC devices. (A) Schematic of the MSC-16 illustrating the TiN (1–4) and Au (5–8) electrodes in rows of different sizes aligned in right and left columns (R and L), designed to fit on nerves of different diameters (from 100 to 1000 µm). The table list the surface geometric area of the electrodes. (B) Fabrication process: thiol-ene/acrylate thin films were used for the transference of Au. The TiN was sputtered and etched. (C) Photographs of the silicone and different designs of MSC cuffs used in the study, the arrows indicate the eyelids included for suture (left). Cross section view of silicone cuff with thick walls, compared to the thin MSC device (right). Ruler in C shows the scale in mm.