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. 2018 Nov 6;8:16372. doi: 10.1038/s41598-018-34678-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the dimeric structures of the five gut bacterial GUSs. Top and side views of the dimers of the tetrameric (a) BifdGUS, (b) RgGUS, (c) CpGUS (d) EcGUS and (e) BfGUS. The highlighted loops (red) are located either at the periphery of the TIM barrel (loop 3) or at the jelly-roll domain (α2-helix loop). (a) Each α2-helix loop in BifdGUS stretches to the ABS of the adjacent subunit. Each loop 3 of CpGUS (c) and EcGUS (d) exists in an open form and extends from its own subunit to the ABS of the adjacent subunit. Conversely, both loops 3 are not in contact with the adjacent subunit in RgGUS (b). The dimeric interface of BfGUS (e) is oriented differently than in the other GUSs as the active site of the two monomers do not face each other. See also Supplementary Fig. S2. Structural representations were prepared with the use of the Pymol Molecular Graphics System (version 1.8.4.0 Schrodinger).