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. 2018 Nov 6;8:16392. doi: 10.1038/s41598-018-34304-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Visualization of the transmembrane potential of one of the simulations performed using the biventricular patient-specific mesh (to facilitate the visualization only half of the ventricles is shown in the figure). The simulation presents sustained reentries with ϕ = 0.66 and [ATP_i] = 2 mM. (a) Multiple stimuli were applied to different subendocardial regions to mimic an activation via the Purkinje network. (b) Both ventricles are fully depolarized. No electrical activity inside the small infarct region at the upper region of the LV is found. This behavior holds during the entire simulation. However, inside the larger infarct region we observe persistent electrical activity due to the fractionated propagation of AP waves. (c) The ventricles begin to repolarize. Inside the large infarct region micro-reentries lead to the formation of two fractionated spiral waves. (d) An ectopic beat is generated at the right side of the large infarct region and propagates towards the healthy tissue.