Figure 6.

Mitigation of proinflammation by P. UF1 during L. m expressing 3 DlaT peptides (L. m^3pep) infection. Signr1^−/- mice were orally infected with 10⁹ CFU of L. m (red) or with L. m^3pep (grey). Seven days post-infection, splenic immune responses were analyzed. (A) Representative data of flow plots, percentage (%), and total cell counts of IL-1β⁺, IL-6⁺ and IL-12/23p40⁺ DCs. (B) Representative data of flow plots, percentage (%), and total cell counts of colonic Th17 cells, Th1 cells, Treg cells and IL-10⁺ TGF-β⁺ FoxP3⁺ Tregs. A and B: Representative data from two independent experiments (n = 4 mice/group). The p value in A and B was determined by a two-tailed unpaired t-test. Data are represented as mean ± S.E.M.