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. 2018 Nov 6;8:16388. doi: 10.1038/s41598-018-34592-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Generation and initial screening of neurotoxicant and critical period transcriptional signatures. (a) We generated a critical period signature by differential expression of primary visual cortex (V1) from mouse during the endogenous critical period at postnatal day (P) 26 compared to adult at > P56 using public data (GSE89757) to yield a 176 gene signature. (b) From 1.25 million Comparative Toxicogenomics Database (CTD) records across 4892 chemicals with mRNA relationships, we generated 136 neurotoxicant gene sets that included genes both increased or decreased by a given neurotoxicant (TOX composite gene set; 3-2419 genes per set). (c) We used Hypergeometric tests to assess the likelihood of overlapping genes in the critical period signature with a given TOX composite gene set to reduce the search space to 28 neurotoxicants (threshold of P_adj < 0.05) for downstream analysis. See Table S1 for a complete list of the 136 neurotoxicants and related enrichment statistics.