Table 1.
Inhibition IC50 values [mM] of Sialyl-Lac/LacNAc in comparison to Sialyl-Galβ(1,3)GalNAc O-glycoforms towards H1N1sea and H3N2 influenza virus strains using a neutralization assay.
| IC50 [mM] H1N1sea | IC50 [mM] H3N2 | ||
|---|---|---|---|
| Sialyl-Lac/LacNAc | 3′SL | 0.89 (±0.07) | 0.71 (±0.02) |
| 6′SL | 0.27 (±0.04) | 1.19 (±0.09) | |
| 3′SLN | 2.24 (±0.23) | 0.28 (±0) | |
| 6′SLN | 0.24 (±0.01) | 0.35 (±0.1) | |
| Sialyl-Galβ(1,3) GalNAc | 3-sialyl-Galβ(1,3)GalNAc (3-sialyl core 1) | 3.62 (±0.25) | 0.35 (±0.02) |
| 6-sialyl-Galβ(1,3)GalNAc (6-sialyl core 1) | 3.87 (±0.62) | 0.31 (±0.07) | |
| 3,6-disialyl-Galβ(1,3)GalNAc (3,6-disialyl core 1) | 1.77 (±0.08) | 0.36 (±0.02) | |
| Controls | Galβ(1,3)GalNAc | ≥20 | ≥20 |
| Sucrose | ≥20 | ≥20 |
The errors are represented as standard error of the mean.