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. Author manuscript; available in PMC: 2018 Nov 6.
Published in final edited form as: Alzheimers Dement. 2018 May 21;14(10):1281–1292. doi: 10.1016/j.jalz.2018.04.011

Fig. 1.

Fig. 1.

Baseline and longitudinal PET data support a classification in three sequential stages according to cortical and striatal signals. Top row: PET data in the striatum versus cortex from the HABS (C11PiB) and the ADNI (F18Florbetapir). Striatum can distinguish two groups among individuals with high cortical Aβ. Subjects with PET-Aβ stage 1 have striatal signal in the same range compared with low-Aβ CN participants, and subjects with PET-Aβ stage 2 participants have striatal signal above the 99th percentile of low-Aβ normal participants. Bottom row: Spaghetti plots showing longitudinal change in striatal and cortical Aβ PET in both cohorts over a 3-year follow-up (Table 2 and text for statistics). Plain arrows indicate the most frequent transition observed. The dotted red arrow highlights the backward transitions observed in ADNI only. Abbreviations: Aβ, amyloid β; ADNI, Alzheimer’s Disease Neuroimaging Initiative; CN, clinically normal; HABS, Harvard Aging Brain study.