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. Author manuscript; available in PMC: 2018 Nov 6.
Published in final edited form as: Alzheimers Dement. 2018 May 21;14(10):1281–1292. doi: 10.1016/j.jalz.2018.04.011

Fig. 3.

Fig. 3.

MMSE decline and hippocampal atrophy are more severe in individuals with high striatal Aβ than in individuals with very high cortical Aβ. Top and middle rows on the right: In both HABS and ADNI, individuals with high cortical Aβ are subdivided into four PET-Aβ substages, using both a striatal and a very high cortical Aβ threshold—1+: moderately high cortex, low striatum; 1++: very high cortex, low striatum; 21: moderately high cortex, high striatum; 2++: very high cortex, high striatum. Bottom right: hippocampal volumes by PET-Aβ substages in nondemented older adults. Striatal PET-Aβ, but not very high cortical PET-Aβ, is associated with lower hippocampal volumes. Left: MMSE decline by PET-Aβ substages in nondemented older adults. Groups with high striatal Aβ (2+ and 2++) demonstrated the fastest decline. Error bars are 95% confidence intervals. See the last row of Table 3 for statistics. Abbreviations: Aβ, amyloid β; ADNI, Alzheimer’s Disease Neuroimaging Initiative; HABS, Harvard Aging Brain study.