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. 2018 Oct 19;9(82):35313–35326. doi: 10.18632/oncotarget.26238

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Copyright: © 2018 Annesley et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) Kaplan–Meier survival curve of knock-in Wt1^+/R394W mice (n = 76) and wild type (wt) littermates (n = 36). (B) Hemoglobin values of moribund Wt1^+/R394W mice (n = 5, mean hemoglobin 9.74 g/dL ± 1.59) compared to age-matched wt mice (n = 10, mean hemoglobin 12.93 g/dL ± 0.55, p = 0.03). Horizontal bars represent the mean values. Representative bone marrow cytospins are shown of (C) wild type mice and (D) moribund Wt1^+/R394W mice (100×; scale bars are 10 microns). (C) Bone marrow from wt mice demonstrates no significant dysplasia in the myeloid or erythroid lineages; black arrows indicate normal erythroid precursors. In (D), red arrows denote early and late erythroid precursors with dysplastic changes in Wt1^+/R394W bone marrow.