Table 2. Distribution of hematologic phenotype by bone marrow genotype of transplanted mice.
| Disease Phenotype | Wild type BM (n = 10) | Wt1+/R394W BM (n = 12) | Flt3/+/ITD BM (n = 12) | Flt3/+/ITD/Wt1+/R394W BM (n = 12) |
|---|---|---|---|---|
| Normal | 9 (90%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Infection | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| MDS | 1 (10%) | 12 (100%) | 0 (0%) | 2 (17%) |
| MPN | 0 (0%) | 0 (0%) | 9 (75%) | 0 (0%) |
| MDS/MPN | 0 (0%) | 0 (0%) | 0 (0%) | 8 (67%) |
| Evolving AML | 0 (0%) | 0 (0%) | 2 (17%) | 1 (8%) |
| AML | 0 (0%) | 0 (0%) | 0 (0%) | 1 (8%) |
| T-ALL | 0 (0%) | 0 (0%) | 1 (8%) | 0 (0%) |
Abbreviations: BM = bone marrow, MDS = myelodysplastic syndrome, MPN = myeloproliferative neoplasm, AML = acute myeloid leukemia, T-ALL = T-cell acute lymphoblastic leukemia.