Table 1. Model parameters.

Parameter	k0 [ms−1]	k1 [mV−1]
Model 1
ka	21.066 ± 3.341	0.025607 ± 0.003094
kd	4.9846 ± 0.7914	−0.041864 ± 0.003096
ko	79.237 ± 26.85	0.012616 ± 0.007132
kc	0.19986 ± 0.0667	−0.0042279 ± 0.006837
koi	4,059.03	0.012616
kci	75,377.9	−0.0042279
kos	14,288.7	0.012616
kcs	65,148.3	−0.0042279
ki	0.0041372 ± 0.003587	0.0081037 ± 0.02083
kr	0.025486 ± 0.006448	−0.035336 ± 0.005562
kio	0.00037617 ± 0.000664	0.0081037
kro	0.007445 ± 0.03127	−0.035336
kis	0.0102506 ± 0.004418	0.0042311 ± 0.006932
krs	3.1687 × 10−6 ± 1.455 × 10−6	−0.061102 ± 0.006231
kiso	0.00045328 ± 0.00005917	0.0042311
krso	0.00025328 ± 0.0004963	−0.061102
a	1.8728 ± 0.2528
b	7.0396 ± 0.8488
Model 2
ka	0.901	−0.079
kd	0.055	−0.167
ko	41.126	0.021
kc	0.255	0.01

The table contains the estimated parameters for Model 1 (Fig. 3 A) and Model 2 (Fig. 7 A), given as mean and SD. All rate constants have the form $k=k_{}^0\times e^{k_{}^1\times V}$. The a and b values represent allosteric factors. SD values are not given for some of the Model 1 parameters, because those parameters were not estimated but calculated (see Materials and methods). SD values are not given for Model 2, which was truncated from Model 1 and adjusted to describe only a subset of the VC data. The voltage sensitivity factors k¹ can take both positive and negative values and their SDs should be interpreted as absolute values on a scale of approximately −0.15 to +0.15 mV⁻¹, typical of voltage-gated channels. In contrast, the SDs of the pre-exponential factors k⁰ and allosteric factors a and b should be interpreted as relative to the estimated mean.