Table 1. Structures of TRP channels.
| TRP channel | PDB ID | Resolution (Å) | Residue forming the gate | R (Å) | π-Bulge? | Conserved asparagine | State | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPV1 | 5IRZ | 2.95 | I679 | 0.7 | Yes | N676 | In | Gao et al., 2016 |
| TRPV1 | 5IS0 | 3.43 | I679 | 0.7 | Yes | N676 | In | Gao et al., 2016 |
| TRPV1 | 3J5P | 3.275 | I679 | 0.8 | Yes | N676 | In | Liao et al., 2013 |
| TRPV1 | 3J5R | 4.2 | I679 | 1.8 | Yes | N676 | Out | Cao et al., 2013b |
| TRPV1 | 5IRX | 2.95 | I679 | 2.8 | Yes | N676 | In | Gao et al., 2016 |
| TRPV1 | 3J5Q | 3.8 | I679 | 3.0 | Yes | N676 | In | Cao et al., 2013b |
| TRPV2 | 5AN8 | 3.8 | M643 | 0.9 | No | N637 | Out | Zubcevic et al., 2016 |
| TRPV2 | 5HI9 | 4.4 | M645 | 1.1 | No | N639 | Out | Huynh et al., 2016 |
| TRPV2 | 6BWM | 3.9 | M643 not resolved | — | No | N637 | Out | Zubcevic et al., 2018 |
| TRPV2 | 6BWJ | 3.1 | M643 partially resolved | — | No | N637 | Out | Zubcevic et al., 2018 |
| TRPV3 | 6DVW | 4.3 | M677 | 0.9 | No | N671 | Out | Singh et al., 2018a |
| TRPV3 | 6DVY | 4.0 | M677 | 0.9 | No | N671 | Out | Singh et al., 2018a |
| TRPV3 | 6DVZ | 4.24 | I674 | 2.4 | Yes | N671 | In | Singh et al., 2018a |
| TRPV4 | 6BBJ | 3.8 | M714 | 0.8 | No | N708 | Out | Deng et al., 2018 |
| TRPV5 | 6B5V | 4.8 | M578 | 0.8 | No | N572 | Out | Hughes et al., 2018a |
| TRPV5 | 6DMU | 3.9 | I575 | 3.3 | Yes | N572 | In | Hughes et al., 2018b |
| TRPV6 | 6BO8 | 3.6 | I575 | 2.9 | Yes | N572 | In | McGoldrick et al., 2018 |
| TRPV6 | 6BO9 | 4.0 | I575 | 3.1 | Yes | N572 | In | McGoldrick et al., 2018 |
| TRPV6 | 6BOB | 3.9 | M577 | 0.8 | No | N571 | Out | McGoldrick et al., 2018 |
| TRPV6 | 6BOA | 4.2 | M578 | 0.8 | No | N572 | Out | McGoldrick et al., 2018 |
| TRPV6 | 5IWK | 3.247 | M577 | 0.6 | No | N571 | Out | Saotome et al., 2016 |
| TRPV6 | 5WO6 | 3.31 | M577 | 0.7 | No | N571 | Out | Singh et al., 2017 |
| TRPV6 | 6D7S | 4.34 | I575 | 2.7 | Yes | N572 | In | Singh et al., 2018b |
| TRPV6 | 6D7T | 4.44 | M578 | 0.8 | No | N572 | Out | Singh et al., 2018b |
| TRPA1 | 3J9P | 4.24 | I957 | 1.4 | Yes | N954 | In | Paulsen et al., 2015 |
| TRPM2 | 6CO7 | 3.07 | I1082 | 0.9 | Yes | N1079 | In | Zhang et al., 2018 |
| TRPM4 | 6BQV | 3.1 | I1040 | 0.7 | Yes | N1037 | In | Autzen et al., 2018 |
| TRPM4 | 6BQR | 3.2 | I1040 | 0.8 | Yes | N1037 | In | Autzen et al., 2018 |
| TRPM4 | 5WP6 | 3.8 | I1040 | 1.0 | Yes | N1037 | In | Winkler et al., 2017 |
| TRPM4 | 6BCJ | 3.14 | I1036 | 0.9 | Yes | N1033 | In | Guo et al., 2017 |
| TRPM4 | 6BCL | 3.54 | I1036 | 0.8 | Yes | N1033 | In | Guo et al., 2017 |
| TRPM4 | 6BCO | 2.88 | I1036 | 0.9 | Yes | N1033 | In | Guo et al., 2017 |
| TRPM4 | 6BCQ | 3.25 | I1036 | 0.9 | Yes | N1033 | In | Guo et al., 2017 |
| TRPM7 | 6BWD | 3.7 | I748/I931 | 0.8 | Yes | N745/N928 | In | Duan et al., 2018b |
| TRPM8 | 6BPQ | 4.1 | L973 | 0.8 | No | N967 | Out | Yin et al., 2018 |
| TRPC3 | 6CUD | 3.3 | I658 | 0.7 | No | N652 | Out | Fan et al., 2018 |
| TRPC3 | 5ZBG | 4.36 | I655 | 1.8 | S6 distorted | N652 | In | Tang et al., 2018 |
| TRPC4 | 5Z96 | 3.28 | I617 | 0.9 | Yes | N614 | In | Duan et al., 2018b |
| TRPC4 | 6G1K | 3.6 | I617 | 0.8 | Yes | N614 | In | Vinayagam et al., 2018 |
| TRPC6 | 5YX9 | 3.8 | I724 | 1.5 | S6 distorted | N721 | In | Tang et al., 2018 |
| TRPP2 | 5MKE | 4.3 | L677 | 1.9 | S6 distorted | N674 | In | Wilkes et al., 2017 |
| TRPP2 | 5MKF | 4.2 | L677 | 1.0 | S6 distorted | N674 | Out | Wilkes et al., 2017 |
| TRPP2 | 5T4D | 3.0 | L677 | 0.6 | Yes | N674 | In | Shen et al., 2016 |
| TRPP2 | 5K47 | 4.22 | L677 | 0.7 | Yes | N674 | In | Grieben et al., 2017 |
| TRPP2 | 6D1W | 3.54 | I680 | 2.3 | No | N674 | Out | Zheng et al., 2018 |
| TRPP2 | 5Z1W | 3.38 | I560 | 2.6 | No | N554 | Out | Su et al., 2018b |
| TRPP2 | 6DU8 | 3.11 | I560 | 0.5 | No | N554 | Out | Hulse et al., 2018 |
| TRPP2 | 6A70 | 3.6 | L677 | 0.9 | Yes | N674 | In | Su et al., 2018a |
| NOMPC | 5VKQ | 3.55 | I1554 | 0.8 | Yes | Q1551 | In | Jin et al., 2017 |
| TRPML1 | 5WJ5 | 3.72 | I514 | 0.9 | Yes | S511 | In | Schmiege et al., 2017 |
| TRPML1 | 5WJ9 | 3.49 | I514 | 2.4 | Yes | S511 | In | Schmiege et al., 2017 |
| TRPML1 | 5WPQ | 3.64 | I514 | 0.9 | Yes | S511 | In | Chen et al., 2017 |
| TRPML1 | 5WPT | 3.75 | I514 | 0.8 | Yes | S511 | In | Chen et al., 2017 |
| TRPML1 | 5WPV | 3.59 | I514 | 0.6 | Yes | S511 | In | Chen et al., 2017 |
| TRPML3 | 6AYE | 4.06 | I498 | 0.8 | Yes | S495 | In | Zhou et al., 2017 |
| TRPML3 | 6AYF | 3.62 | I498 | 3.3 | Yes | S495 | In | Zhou et al., 2017 |
| TRPML3 | 5W3S | 2.94 | I498 | 1.0 | Yes | S495 | In | Hirschi et al., 2017 |
Columns contain PDB ID, resolution, residue forming the gate, pore radius at the level of the gate, presence/absence of the π-bulge in the S6 helix, conserved asparagine, and conformational state of the conserved asparagine (inside or outside the pore). The pore radius at the level of the gate was estimated using HOLE (Smart et al., 1996). For TRPV2 6BWM and 6BWJ structures, the side chain of the residue forming the gate was either not resolved or resolved partially; the pore radius was not estimated for these structures.