Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 5;215(11):2796–2814. doi: 10.1084/jem.20181442

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Fan et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 3. — CD49b⁺ Treg cells are more suppressive than other Treg cells in vitro, but all Treg populations converge on the CD49b⁺ state under inflammatory conditions in vivo. (A and B) Treg cells and preactivated Teff cells were cotransferred into T cell–deficient recipients. Shown is the expression of CD25, Ki-67, and IFN-γ in Teff cells and CD49b in Treg cells recovered from skin-draining PLNs at various times after transfer. (C) Treg-mediated suppression of naive T cell thymidine incorporation in vitro. (D) Treg-mediated suppression of naive T cell CD25 expression in vitro. (E) Treg-mediated suppression of dendritic cell costimulatory molecule expression in vitro. a.u., arbitrary units. (F) CTLA-4 expression by splenic Treg and Tconv cell subsets. Data are representative of two (A and B) or three (C–F) independent experiments. Bars depict means ± SD; ***, P ≤ 0.001 by two-way ANOVA; ns, not significant. See also Fig. S3.