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. 2018 Nov 5;215(11):2796–2814. doi: 10.1084/jem.20181442

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© 2018 Fan et al.

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Figure 4. — Treg cells stably express CD49b in a maturation-dependent manner. (A) Percentage of CD49b⁺ cells among Treg cells stimulated in culture with α-CD3/CD28 and IL-2 for 4 or 8 d. (B) Percentage of CD62L⁺ or CD49b⁺ cells among aTreg cells in tissues of 5-d-old or 8-wk-old mice. (C) Expression of Rag2^GFP in Treg subsets from 4-wk-old Rag2^GFP mice. (D) Quantification of C. **, P ≤ 0.01 by paired t test; ns, not significant. (E) The indicated Foxp3^GFP Treg subsets were separately transferred into sublethally irradiated congenic Foxp3^GFP mice. Shown is the expression of CD49b versus dilution of CTV by transferred Treg cells recovered from spleen after 6 d. (F) Quantification of CD49b expression by transferred Treg cells. Data are representative of two independent experiments. Bars depict means ± SD.